中国临床药理学杂志2017，Vol.33Issue(13)：1171-1173,3.DOI:10.13699/j.cnki.1001-6821.2017.13.001
辛伐他汀联合银杏叶片对心性猝死综合征患者的血脂及颈动脉粥样硬化斑块的影响
Effects of simvastatin and Ginkgo tablets on plasma lipids and carotid atherosclerotic plaque in patients with sudden cardiac death syndrome
摘要
Abstract
Objective To study the effects of simvastatin and Ginkgo tablets on blood lipid and carotid atherosclerotic plaque in patients with sudden cardiac death syndrome (SIDS).Methods The 300 patients were randomly divided into two groups:treatment group (simvastatin 20 mg + Ginkgo tablets 24 mg) and control group (simvastatin 20 mg).Each group had 150 cases.Each one tablet,three times a day.The course of treatment in both groups were six months.During the course of treatment,the blood lipid level was measured once every three months by the biochemical detection method.After the treatment,the plaque area was measured by carotid color Doppler ultrasound.Results At the time 6 months after treatment,the levels of total cholesterol (TC) in treatment group and control group were (3.67 ± 0.45),(4.21 ± 0.24) mmol· L-1;triacylglycerol (TG) in that two groups were (1.44 ± 0.47),(2.00 ± 0.68) mmol · L-1;high densitylipoprotein-cholesterol (HDL-C) in that two groups were (0.98 ± 0.12),(0.90 ± 0.13) mmol · L-1;and low densitylipoprotein-cholesterol (LDL-C) in that two groups were (1.84 ± 0.41),(2.17 ± 0.49)mmol · L-1.Compared with before treatment and compared with control group after treatment,the difference was statistically significant (all P ＜ 0.05).Before treatment,the area of the plaques in the treatment group and control group were (6.70 ± 3.56),(6.38 ± 3.68) mm2.But after treatment,the area of the plaques in the treatment group and control group were (4.21 ± 2.16),(4.77 ± 2.70) mm2 with not statistically significant (all P ＞0.05).Conclusion Simvastatin combined with Ginkgo tablets could decrease TC,LDL-C and TG levels in patients with SIDS and reduce the plaque area.关键词
辛伐他汀/银杏叶片/心性猝死综合征/颈动脉粥样硬化斑块Key words
simvastatin/Ginkgo tablets/sudden cardiac death syndrome/carotid atherosclerotic plaque分类
医药卫生引用本文复制引用
赵丹生,马晓峰..辛伐他汀联合银杏叶片对心性猝死综合征患者的血脂及颈动脉粥样硬化斑块的影响[J].中国临床药理学杂志,2017,33(13):1171-1173,3.基金项目
青海省卫生计生科研基金资助项目(2016-wjqn-05) （2016-wjqn-05）
