中国临床药理学杂志2017，Vol.33Issue(13)：1174-1176,1180,4.DOI:10.13699/j.cnki.1001-6821.2017.13.002
依达拉奉注射液治疗颅脑外伤脑梗死的临床研究
Clinical trial of edaravone in the treatment of traumatic cerebral infarction
摘要
Abstract
Objective To study the clinical efficacy and safety of edaravone in the treatment of traumatic cerebral infarction.Methods A total of 72 patients with traumatic cerebral infarction were randomly divided into the control group (n =36) and the treatment group (n =36).The control group received conventional treatments including intracranial pressure control,nerve nutrition and microcirculation regulation.The patients in treatment group were given intravenous infusion of edaravone 20 mL + 0.9％ NaC1 200 mL on the basis of the conventional treatment,bid,14 d.The changes of hemorheologic parameters were measured and compared between the two groups respectively.The total effective rate were evaluated according to the Glasgow scores,and the safety of clinical medication was evaluated.Results The total effective rate of the treatment group was 91.67％ (33/36 cases) while that of the control group was 72.22％ (26/36 cases),with statistically significant difference between the two groups (P ＜ 0.05).Mter treatment,high shear whole blood viscosity in the treatment group and the control group were (4.73 ± 0.56),(5.36 ± 0.78) mPa · s respectively,while low shear whole blood viscosity were (8.15 ± 1.03),(9.54 ± 1.26) mPa · s,plasma viscosity were (1.41 ± 0.15),(1.76 ± 0.19) mPa · s,red blood cell pressure were (37.15 ± 3.21) ％,(43.17 ± 4.03)％,fibrin deposition were (3.58 ± 0.45),(4.67 ±0.54)g· L-1,and the differences of all the parameters above between the two groups were statistically significant (P ＜ 0.05).The incidence of adverse drug reactions in the treatment group and control group were 5.56％ (1/36 cases) and 2.78％ (2/36 cases) respectively,while no statistical significance was observed (P ＞ 0.05).Conclusion Edaravone is able to improve hemorheology indexes in patients with traumatic brain injury complicated with cerebral infarction.The treatment effect is better than the routine nervous medical treatment,and edaravone has a positive effect on the clinical treatment of traumatic brain injury complicated with cerebral infarction.关键词
依达拉奉/颅脑外伤/脑梗死/血液流变学Key words
edaravone/traumatic brain injury/cerebral infarction/hemorheology分类
医药卫生引用本文复制引用
赵贤军,任海军,潘亚文,康暐,候博儒..依达拉奉注射液治疗颅脑外伤脑梗死的临床研究[J].中国临床药理学杂志,2017,33(13):1174-1176,1180,4.基金项目
甘肃省自然科学基金资助项目(1506RJZA222) （1506RJZA222）
