中国临床药理学杂志2017，Vol.33Issue(13)：1191-1193,1197,4.DOI:10.13699/j.cnki.1001-6821.2017.13.007
甲氧明对全身麻醉下择期进行非心脏手术患者全诱导期生命体征的影响
Effects of methoxamedrine on the vital signs of patients undergoing elective non-cardiac surgery during induction of general anesthesia
摘要
Abstract
Objective To investigate the effects of methoxamedrine on the vital signs of patients undergoing elective non-cardiac surgery during induction of general anesthesia.Methods One hundred and forty elderly patients undergone elective non-cardiac surgery during induction of general anesthesia were randomly divided into control group and treatment group,each group 70 cases,using the random table.The treatment group was pumped methoxamedrine for 4 μg · kg-1 · min-1 by continuous micro intravenous infusion before general anesthesia induction,while control group was pumped 0.9％ NaCl.The blood pressure,heart rate,the indexes of myocardial enzymes and adverse drug reactions were compared on 5 min before induction of anesthesia (T0),2 min after induction (T1),intubation (T2),1 min after intubation,5 min after intubation (T4),10 min after intubation (T5) in two groups.Results The systolic blood pressure in treatment group at T1,T2,T3,T4 were (135.07 ± 27.78),(131.34 ± 33.28),(129.37 ± 37.22),(132.47 ± 32.21) mmHg,and were (124.36 ± 31.07),(103.61 ± 31.49),(157.09 ± 37.40),(124.00 ± 27.13) mmHg in control group.The diastolic blood pressure in treatment group at T1,T3,T4 were (65.44 ± 8.34),(75.47 ± 11.24),(78.59 ± 12.57)mmHg,and were (72.83 ±8.15),(91.25 ±8.38),(71.49 ±9.80) mmHg in control group.The heart rate in treatment group at T1 and T3 were (66.03 ±9.75),(70.71 ±10.16) times · min-1,had significant difference with those in control group,which were (76.64 ± 9.33),(80.43 ± 8.32) times · min-1 (P ＜ 0.05).At T6,the levels of creatine kinase isoenzyme-MB in treatment group and control group were (0.84 ± 0.23),(1.54 ± 0.22) U · L-1,with significant difference (P ＜0.05).The number of bradycardia,nausea and vomiting and restlessness were 2 cases (2.86％),6 cases (8.57％),4 cases (5.71％) in control group,while there were2 cases (2.86％),5 cases (7.14％),3 cases (4.29％) in treatment group,with no significant difference (P ＞0.05).There were 2 cases (2.86％) of tachycardia,3 cases (4.29％) of hypotension,the dosage of ephedrine was (3.25 ± 2.07) mg,had significant difference with those in control group,which were 10 cases (14.29％),16 cases (22.86％),(6.21 ± 1.68) mg (P ＜ 0.05).Conclusion Methoxamedrine can be pumped by continuous micro intravenous infusion for patients undergoing elective non-cardiac surgery during induction of general anesthesia to maintain the stability of heart rate and blood pressure,reduce the incidence of adverse reactions and reduce myocardial injury.关键词
甲氧明/全身麻醉/诱导期/血流动力学Key words
methoxamedrine/general anesthesia/induction period/hemodynamics分类
医药卫生引用本文复制引用
吴爱玲,杨勇,华薇,叶丹丽..甲氧明对全身麻醉下择期进行非心脏手术患者全诱导期生命体征的影响[J].中国临床药理学杂志,2017,33(13):1191-1193,1197,4.基金项目
四川省卫生厅科研基金资助项目(120292) （120292）
