中国临床药理学杂志2017，Vol.33Issue(13)：1198-1200,3.DOI:10.13699/j.cnki.1001-6821.2017.13.009
前列益康胶囊治疗非特异性前列腺炎的临床研究
Clinical trial of Qianlie Yikang capsule in the treatment of patients with nonspecific prostatitis
摘要
Abstract
Objective To evaluate the clinical effect of Qianlie Yikang capsules on the levels of prostaglandin E2 (PGE2) and interleukin-8 (IL-8) in serum and prostatic fluid in patients with nonspecific prostatitis.Methods Eighty patients with nonspecific prostatitis were randomly divided into control group and treatment group,40 cases in each group.Control group was orally given Pule'an tablets 2.0 g,3 times a day.Treatment group was treated with Qianlie Yikang capsules 1.5 g,3 times a day,orally.Before and after treatment,the levels of serum and prostatic fluid PGE2,IL-8 and clinical efficiency in two groups were compared.Results The clinical efficiency of treatment group was 92.50％ (37/40 cases),had significant difference with that in control group,which was 75.00％ (30/40 cases,P ＜ 0.05).After treatment,the serum PGE2 of treatment group and control group were (159.76 ± 16.34),(190.65 ± 17.56) ng · L-1,IL-8 were (2.28 ± 0.32),(3.08 ± 0.22) ng· L-1,with significant difference (P ＜ 0.05).After treatment,the prostatic fluid PGE2 of treatment group and control group were (227.46 ±20.84),(309.46 ± 19.39) ng·L-1,IL-8 were (3.12±0.43),(4.77 ± 0.67) ng · L-1,with significant difference (P ＜0.05).There was no significant adverse reactions in two groups.Conclusion The Qianlie Yikang capsules can significantly reduce the serum and prostatic fluid PGE2,IL-8 levels in patients with nonspecific prostatitis,and have good clinical effect.关键词
前列益康胶囊/非特异性前列腺炎/前列腺素E2/白细胞介素-8Key words
Qianlie Yikang capsule/nonspecific prostatitis/prostaglandin E2/interleukin-8分类
医药卫生引用本文复制引用
何光远,赵健琦,张四喜,宋瑛世,李付彪..前列益康胶囊治疗非特异性前列腺炎的临床研究[J].中国临床药理学杂志,2017,33(13):1198-1200,3.基金项目
吉林省科技发展计划基金资助项目(20130206038YY) （20130206038YY）
