中国临床药理学杂志2017，Vol.33Issue(13)：1237-1239,3.DOI:10.13699/j.cnki.1001-6821.2017.13.019
薏苡叶水提液对小鼠抗疲劳与耐缺氧作用的实验研究
Experimental study of Coix lacryma-jobi (L.) leaf's water extract on the anti-fatigue and hypoxia tolerance function in mice
摘要
Abstract
Objective To study the anti-fatigue and hypoxia tolerance function of Coix lacryma-jobi leaf's water extract in mice.Methods Normal male mice were averagely selected and divided into four groups by weight:control group,low dose,medium dose and high dose experimental groups.Coix lacryma-jobi leaf's water extract of different dose (1.5,4.5,7.5 g · kg-1) was given into the mice's stomach respectively in three experimental groups and distilled water was given in control group,every day for a continuous 14 days.Burdened swimming test and hypoxia tolerance test were conducted in mice to determine their swimming time and death time.Dissociating the mouse's liver,weighing the mouse's liver and calculating the liver weight coefficient.Results The burdened swimming time of the high dose group,medium dose group and low dose group were respectively 6.74,10.47,5.51 min.The hypoxia tolerance time of the high dose group,medium dose group and low dose group were respectively 46.48,54.96,54.90 min.The liver weight coefficient of the high dose group,medium dose group and low dose group were respectively 0.054,0.050,0.051.Compared with the control group,the burdened swimming time of the medium dose group was longer than that of the control group with significantly (P ＜ 0.05).The death time of the low dose group and the medium dose group were prolonged than that of the control group with significantly(all P ＜0.01).Weighing the mouse's liver and the liver weight coefficient in three experimental groups were all higher than the control group with significantly (all P ＜ 0.05).Conclusion Coix lacryma-jobi leaf's water extract had anti-fatigue and hypoxia tolerance function in mice.关键词
惹苡叶水提液/抗疲劳/耐缺氧/肝重系数/游泳Key words
Coix lacryma-jobi (L.) leaf's water extract/anti-fatigue/hypoxia tolerance/liver weight coefficient/swimming分类
医药卫生引用本文复制引用
梁寻杰,卢棉,李舒婷,韦邱梦,黄锁义,王露瑶..薏苡叶水提液对小鼠抗疲劳与耐缺氧作用的实验研究[J].中国临床药理学杂志,2017,33(13):1237-1239,3.基金项目
国家自然科学基金资助项目(81360684) （81360684）
广西自然科学基金资助项目(2011GXNSFA018046) （2011GXNSFA018046）
广西中医药科技专项基金资助项目(GZKZ 10-128) （GZKZ 10-128）
广西中医药管理局课题基金资助项目(gzzc1047) （gzzc1047）
广西医学科学实验中心开放基金专项基金资助项目(KFJJ2011-04) （KFJJ2011-04）
国家级和自治区级大学生创新创业训练计划立项项目基金资助项目(201610599003) （201610599003）
