中国临床药理学杂志2017，Vol.33Issue(14)：1298-1300,3.DOI:10.13699/j.cnki.1001-6821.2017.14.003
硝苯地平控释片治疗老年单纯性收缩期高血压的临床研究
Clinical trial of nifedipine controlled-release tablets in the treatment of elderly isolated systolic hypertension
摘要
Abstract
Objective To compare the clinical efficacy and safety of nifedipine controlled-release tablets and felodipine sustained release tablets in the treatment of elderly isolated systolic hypertension.Methods A total of 76 elderly patients with isolated systolic hypertension were randomly divided into control group and treatment group with 38 cases per group.Control group was given felodipine sustained release tablets 5 rag,qd,oral.Treatment group was given nifedipine controlled-release tablets 30 mg,qd,oral.Two groups were treated for 6 weeks.The clinical efficacy,blood pressure and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 92.11％ (35/38 cases) and 73.68％ (28/38 cases).The systolic blood pressure in treatment and control groups were (129.28 ± 13.02),(136.35 ± 14.09) mmHg,with significant difference (P ＜ 0.05).The adverse drug reactions in treatment group were dizziness and edema,which in control group were dizziness,edema and rash.The incidences of adverse drug reactions in treatment and control groups were 5.26％ and 7.89％,without significant difference (P ＞ 0.05).Conclusion Nifedipine controlled-release tablets had a definitive clinical efficacy in the treatment of isolated systolic hypertension in the elderly,which are better than felodipine sustained release tablets,without increasing the incidence of adverse drug reactions.关键词
硝苯地平控释片/非洛地平缓释片/老年单纯性收缩期高血压/安全性Key words
nifedipine controlled-release tablet/felodipine sustained release tablet/isolated systolic hypertension in the elderly/safety分类
医药卫生引用本文复制引用
王士强,唐杨章,张怀金,吕留强,张友计,赵立..硝苯地平控释片治疗老年单纯性收缩期高血压的临床研究[J].中国临床药理学杂志,2017,33(14):1298-1300,3.基金项目
淮北市科技计划基金资助项目(20120314) （20120314）
