中国临床药理学杂志2017，Vol.33Issue(14)：1304-1306,3.DOI:10.13699/j.cnki.1001-6821.2017.14.005
羟苯磺酸钙胶囊联合丹参注射液治疗老年2型糖尿病早期视网膜病变的临床疗效
Clinical trial of calcium dobesilate capsules combined with Danshen injection in the treatment of elderly patients with early diabetic retinopathy
摘要
Abstract
Objective To observe the clinical efficacy and safety of cal cium dobesilate capsules combined with Danshen injection in the treatment of elderly patients with early diabetic retinopathy.Methods A total of 58 elderly patients with early diabetic retinopathy were randomly divided into the control group and treatment group with 29 cases per group.Control group was given calcium dobesilate 0.5 g,tid,oral.Treatment group was treated with Danshen injection 20 mL,qd,intravenous drip,on the basis of the control group.Two groups were treated for 3 months.The clinical efficacy,serum levels of vascular endothelial growth factor (VEGF),insulin-like growth factor 1 (IGF-1) and high sensitive C-reactive protein (hs-CRP),adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 93.10％ (27/29 cases) and 72.41％ (21/29 cases) with statistically significant difference (P ＜0.05).After treatment,the main indexes in treatment and control groups were compared:VEGF were (82.32 ± 9.73),(105.24±10.05)pg · mL-1;IGF-1 were (89.66 ±8.79),(124.24 ±9.86)ng · mL-1;hs-CRP were (3.98 ± 0.52),(6.76 ± 0.83) mg · L-1,the differences were statistically significant (P ＜ 0.05).The adverse drug reactions in treatment group were based on facial flushing,nausea and vomiting,which in control group were nausea and vomiting,lack of appetite.The incidences of adverse drug reaction in treatment and control groups were 10.34％ and 6.90％ without significant difference (P ＞ 0.05).Conclusion Calcium dobesilate capsules combined with Danshen injection have a definitive clinical efficacy in the treatment of elderly patients with early diabetic retinopathy,which can significantly reduce the patients' serum levels of VEGF,IGF-1 and hs-CRP,without increasing the incidence of adverse drug reactions.关键词
羟苯磺酸钙胶囊/丹参注射液/2型糖尿病早期视网膜病变/安全性Key words
calcium dobesilate capsule/Danshen injection/type 2 early diabetic retinopathy/safety分类
医药卫生引用本文复制引用
姜丽萍,庄晓林,吴庆峰,富强,王宏伟..羟苯磺酸钙胶囊联合丹参注射液治疗老年2型糖尿病早期视网膜病变的临床疗效[J].中国临床药理学杂志,2017,33(14):1304-1306,3.基金项目
国家自然科学基金资助项目(81170856) （81170856）
