中国临床医学影像杂志2017，Vol.28Issue(7)：471-474,4.
分化型甲状腺癌术后首次131I治疗前刺激性Tg水平与转移灶的关系
The relationship between first pre-ablation sTg levels and metastasis in postoperative patients with differentiated thyroid carcinoma
摘要
Abstract
Objective:To investigate the relationship between first pre-ablation stimulated thyroglobulin (sTg) and sTg/thyrotropin (TSH) levels and metastasis in postoperative patients with differentiated thyroid carcinoma (DTC).Methods:The study included 106 patients with DTC who had undergone total thyroidectomy and lymphadenectomy.The pre-ablation sTg and TSH of 106 patients were measured one day before first 131I ablation therapy,and the patients undergone 131I-SPECT/CT on 5～7 days after 131I ablation therapy.Patients were divided into two groups as M0 group and M1 group according to the presence and absence of metastases,respectively.The sTg and sTg/TSH value between M0 and M1 were compared by Mann-Whitney rank-sun test.The ROC curves and diagnostic critical point (DCP) were analyzed to evaluate the predictive values of sTg and sTg/TSH.Results:The pre-ablation sTg and sTg/TSH of M1 were significantly higher than those of M0 (U=242.50,P=0.000;U=237.50,P=0.000).Areas under the ROC curve for sTg and sTg/TSH was 0.913 and 0.914.The cut-off values of DCP of sTg and sTg/TSH were 40.60 ng/mL with a sensitivity of 70.21％,specificity of 100％,accuracy of 86.79％,and 0.24 ng/U with a sensitivity,of 80.85％,specificity of 84.92％,accuracy of 88.68％.Conclusion:The pre-ablation sTg and sTg/TSH may be a useful diagnostic marker for predicting metastases before the first 131I ablation therapy.关键词
甲状腺肿瘤/体层摄影术,发射型计算机,单光子/碘Key words
Thyroid neoplasms/Tomography, emission-computed, single-photon/Iodine分类
医药卫生引用本文复制引用
刘永,陈鹏,宋长祥,陆武,杜鹏..分化型甲状腺癌术后首次131I治疗前刺激性Tg水平与转移灶的关系[J].中国临床医学影像杂志,2017,28(7):471-474,4.基金项目
连云港市卫生计生科技项目(201610). （201610）
