中国免疫学杂志2017，Vol.33Issue(8)：1121-1128,8.DOI:10.3969/j.issn.1000-484X.2017.08.001
免疫应答中基因表达的转录延伸调控
Regulation of gene expression via control of transcription elongation during immune responses
摘要
Abstract
Transcription is a multi-stage process that coordinates several steps during the transcription cycle including pre-initiation,initiation and elongation.Recent advances by genome-wide study suggest that control of transcription elongation is a critical step for precise regulation of gene expression across species from Drosophila to mammals.Here we review the molecular mechanisms of how transcription elongation of RNA polymeraseⅡ(PolⅡ) is modulated by the major pausing factors-NELF,DSIF and the positive elongation factor P-TEFb,which is the key player in pause release.We also discuss the potential implications of regulation of transcription elongation in pathogenesis of cancer,inflammation and virus infection.关键词
基因表达/转录延伸/RNA聚合酶Ⅱ/P-TEFb/NELFKey words
Gene expression/Transcription elongation/RNA polymerase Ⅱ/P-TEFb/NELF分类
医药卫生引用本文复制引用
商营利,胡小玉..免疫应答中基因表达的转录延伸调控[J].中国免疫学杂志,2017,33(8):1121-1128,8.基金项目
本文受国家重点基础研究发展计划(973)(No.2015CB943200)、国家自然科学基金优秀青年科学基金项目(81422019)、国家自然科学基金面上项目(81571580)、国家自然科学基金中英人才基金(81661130161)和国家自然科学基金重大研究计划培育项目(91642115)资助. （973）
