中国脑血管病杂志2017，Vol.14Issue(8)：399-404,6.DOI:10.3969/j.issn.1672-5921.2017.08.002
多种造影方式在脑脊髓动静脉畸形复合手术中的应用初探
Preliminary application of multiple angiographic patterns in the hybrid surgery of cerebral and spinal arteriovenous malformations
摘要
Abstract
Objectives To investigate the application modes of indocyanine green (ICG) angiography,digital subtraction angiography (DSA) and methylene blue angiography in the hybrid surgery of cerebral and spinal arteriovenous malformations (AVMs) and to compare the application value of different intraoperative angiographic methods.Methods From July 2013 to December 2015,55 patients treated with hybrid surgery of cerebral and spinal AVMs in Xuanwu Hospital,Capital Medical University were analyzed retrospectively,including 8 patients with cerebral AVM(Spetzler-Martin grade ≥Ⅲ) and 47 with spinal AVM.Their mean age was 33.8±15.6 years.Intraoperative DSA was performed in a hybrid operation room and methylene blue angiography was performed via the feeding artery.ICG angiography was performed in 4 cases in the initial stage as a comparison.Anatomic cure was confirmed by DSA at 3 months after surgery and the results were assessed.Results All 55 patients performed intraoperative DSA,32 underwent methylene blue angiography and 4 performed intraoperative ICG angiography.The frequency of intraoperative DSA was 3.6±1.3 times for each case.After the resection of the first lesion,the residual lesions revealed by DSA accounted for 27.3% (15/55).85.5% (47/55) patients achieved anatomic cure,in which the patients with midbrain AVM (8/8) and spinal AVM 83.0% (39/47) achieved anatomic cure.Three patients were lost to follow up at 1 year after procedure.The median modified Rankin scale (mRS) score of the cerebral AVMs was 2.0 (0.0-3.8).Compared with 3.5 (2.0-4.0) before procedure,there was significant difference (Z=-2.264,P<0.05).The Aminoff score in patients with spinal AVM after procedure was 3.5 (1.0-6.0).Compared with 4.0 (1.0-6.0) before procedure,there was no significant difference (Z=-0.262,P>0.05).The patients with function preservation (function score equal or better than pre-operation) accounted for 88.5% (46/52).Conclusions Intraoperative DSA could precisely localize the nidi and verify the complete resection.Intraoperative methylene blue angiography could selectively reveal the feeding artery supplied nidi in the operative field and identify the angioarchitecture.ICG angiography could reveal the structures of nidi on the surface of the operation area.The intraoperative methylene blue angiography could replace ICG angiography and achieve the treatment target of anatomical cure of the hybrid surgery of the cerebral and spinal cord vascular malformations.关键词
颅内动静脉畸形/脊髓动静脉畸形/术中造影/亚甲蓝/治疗性Key words
Cerebral arteriovenous malformation/Spinal arteriovenous malformation/Intraoperative angiography/Methylene blue/Therapy引用本文复制引用
洪韬,张鸿祺,李桂林,何川,叶明,胡鹏,马永杰..多种造影方式在脑脊髓动静脉畸形复合手术中的应用初探[J].中国脑血管病杂志,2017,14(8):399-404,6.基金项目
国家自然科学基金(81171165、 81671202) （81171165、 81671202）
北京市医管局扬帆计划(ZY201309) （ZY201309）
北京市科委重点项目(D161100003816001) （D161100003816001）
