中国实用外科杂志2017，Vol.37Issue(8)：911-914,4.DOI:10.19538/j.cjps.issn1005-2208.2017.08.20
侵袭性纤维瘤病48例临床特点及诊治分析
Clinical characteristics, diagnosis and treatment of aggressive fibromatosis: An analysis of 48 cases
摘要
Abstract
Objective To investigate the clinical characteristics, diagnosis, treatment and prognosis of aggressive fibromatosis (AF). Methods The clinical data of 48 patients of AF admitted in the Department of Abdominal Emergency Surgery, the First Affiliated Hospital of Dalian Medical University from March,2002 to March,2017 were analyzed retrospectively. The clinical features, immunophenotype, treatment and prognosis of patients of AF were analyzed retrospectively. Results All the cases included 21 males and 27 females, aged 1 to 76 years, with the most cases (13 cases) aged 31-40 years. There were 34 cases (70.8%) of extra-abdominal AF, 9 cases (18.8%) of abdominal wall AF, 5 cases (10.4%) of intra-abdominal AF. The positive rate ofβ-catenin and vimentin were 100.0%and 87.5%respectively. Forty patients were followed-up, of which 4 recurred after operation.Conclusion AF occurs in young women, high incidence of 31-40 years old, in addition to the biological behavior of the tumor itself and the characteristics of conventional imaging, immunohistochemistryβ-catenin, vimentin positive are the performance of AF. Surgical resection is the most important treatment. Preoperative diagnosis should be made and the risk of complete resection should be adequately assessed and the risk of surgical trauma should be used to weigh the organ and dysfunction caused by surgery with the expected behavior of the tumor and the potential efficacy of other treatments. The margins should be sent to the pathology to ensure the R0 resection, reduce the recurrence rate regardless of tumor size.关键词
侵袭性纤维瘤病/手术/免疫组化/复发/病理学Key words
aggressive fibromatosis/surgery/immunohistochemistry/recurrence/pathology分类
医药卫生引用本文复制引用
胡凤林,祁冰,张庆凯,徐贺,刚华忆,尚东..侵袭性纤维瘤病48例临床特点及诊治分析[J].中国实用外科杂志,2017,37(8):911-914,4.基金项目
国家自然科学基金项目(No.81373875) （No.81373875）
辽宁省省直医院改革重点临床科室诊疗能力建设项目(No.LNCCC-A03-2015) （No.LNCCC-A03-2015）
