中国现代手术学杂志2017，Vol.21Issue(3)：161-167,7.DOI:10.16260/j.cnki.1009-2188.2017.03.001
12基因模型对乳腺导管原位癌复发风险预测的回顾性分析
Retrospective Analysis on 12-Genes DCIS Score Model Predicting the Recurrence Risk of Ductal Carcinoma in Situ of the Breast
摘要
Abstract
Objective To evaluate the efficacy of 12-genes DCIS score model predicting the prognosis of ductal carcinoma in situ (DCIS) in Chinese population.Methods A total of 79 DCIS cases with complete clinical data from January 2010 to January 2016 were enrolled into the research.The expression of 12 genes (including Ki67,STK15,Survivin,CCNB1,MYBL2,PR,GSTM1,ACTB,GAPDH,RPLPO,GUS and TFRC) were detected by PCR technique in the 79 postoperative paraffin tissue samples.Then DCIS score were calculated according to the 12-genes model.The correlation factors were analyzed by Logistic regression analysis,and the effect on recurrence/metastasis was studied in different DCIS score groups by Kaplan-Meier test.Results Logistic regression analysis revealed the pathologic nuclear grade was the high risk factors of DCIS recurrence,but other pathologic features (as the size of mass,the ER,PR,HER2 and positive expression of Ki67) was not the related factors of DCIS recurrence.According to DCIS score,79 cases were divided into low risk group (n =30),middle risk group (n =20) and high risk group (n =29),and found tumor recurrence/metastasis in 1 case (3.3％),2 cases(10％)and 4 cases (13.8％) respectively during the follow-up.The analysis of Kaplan-Meier showed that the recurrence time of DCIS was earlier in high risk group than that in other two groups,and the difference was statistical significance (P =0.003).Conclusions The 12-genes model can preliminarily predict the risk of recurrence in DCIS patients in Chinese.Combined with relevant clinical pathologic factors,it can preferably guide the therapeutic decision-making of DCIS.关键词
乳腺肿瘤/导管原位癌/基因模型/复发风险Key words
breast neoplasms/ductal carcinoma in situ/genetic model/recurrence risk分类
医药卫生引用本文复制引用
简文静,唐静,王先明..12基因模型对乳腺导管原位癌复发风险预测的回顾性分析[J].中国现代手术学杂志,2017,21(3):161-167,7.基金项目
深圳市技术开发研究课题(CXZZ20140414170821163)、深圳市科技知识创新计划基础研究项目(JCYJ20130401113354230) （CXZZ20140414170821163）
