中国药业2017，Vol.26Issue(15)：20-22,3.DOI:10.3969/j.issn.1006-4931.2017.15.006
高效液相色谱法测定复方锌布颗粒剂中马来酸氯苯那敏的含量及含量均匀度
Determination of Content and Content Uniformity of Chlorphenamine Maleate in Compound Zinc Gluconate and Ibuprofen Granules by HPLC
冯璐1
作者信息
- 1. 江苏省泰州市食品药品检验所,江苏泰州 225300
- 折叠
摘要
Abstract
Objective To establish an HPLC method for the determination of content and content uniformity of chlorphenamine maleate in Compound Zinc Gluconate and Ibuprofen Granules. Methods The Capcell PAK C18 column(250 mm × 4. 6 mm, 5 μm) was adopted, the mobile phase was 0. 05 mol/L KH2PO4 ( containing 0. 1% triethylamine three, pH was adjusted to 2. 5 by phosphoric acid ) -acetoni-trile ( 80 :20 ) , the flow rate was 1. 0 mL/min, the column temperature was 35 ℃, the wavelength was 263 nm. Results There was a good linear relationship within the range of 0. 006356-0. 2034 g/L ( r=1. 0000 ) . The average recovery was 100. 17%, RSD was 0. 97%( n=9 ) . Conclusion The method is convenient, rapid, effective and accurate for the determination of content and content unifor-mity of chlorphenamine maleate, which can be used in the quality control of Compound Zinc Gluconate and Ibuprofen Granules.关键词
高效液相色谱法/马来酸氯苯那敏/含量均匀度Key words
HPLC/chlorphenamine maleate/content uniformity分类
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冯璐..高效液相色谱法测定复方锌布颗粒剂中马来酸氯苯那敏的含量及含量均匀度[J].中国药业,2017,26(15):20-22,3.
