中国药业2017，Vol.26Issue(15)：38-40,3.DOI:10.3969/j.issn.1006-4931.2017.15.012
瑞舒伐他汀逐日给药与间日给药对血脂的影响
Effect of Alternate-Day and Daily Administration of Rosuvastatin on Serum Lipid Level
袁浩宇 1王鹏 1俞瑜1
作者信息
- 1. 核工业四一六医院,四川成都 610051
- 折叠
摘要
Abstract
Objective To compare the effect of alternate-day and daily administration of rosuvastatin on levels of serum lipid and hs-CRP of patients with coronary artery disease ( CAD ) whose levels of LDL-C are up to standard. Methods Totally 52 patients with CAD whose levels of LDL-C were up to standard were randomly divided into the experimental group and the control group, 26 cases in each group. The experimental group was given rosuvastatin 5 mg daily, while the control group was given rosuvastatin 5 mg every other day. After 6 weeks of treatment, the changes of LDL-C and hs-CRP were examined. Results The average age of the patients was ( 55. 1 ± 8. 91 ) years. After 6 weeks of treatment, the level of LDL-C in the experimental group was ( 87 ± 21 ) mg/dL, which was significantly lower than (106 ±25) mg/dL of the control group( P=0. 008). The level of LDL-C in experimental group was significantly decreased than that in the control group [ ( 0. 8 ± 0. 2 )% vs ( 34. 2 ± 6. 7 )%, P=0. 001 ] . The levels of hs-CRP in the two groups had no significant difference before and after treatment, and the levels of hs-CRP had no significant difference between the two groups after treatment ( P > 0. 05 ) . Conclusion For patients with CAD whose levels of LDL -C are up to standard , maintenance on al ternate -day rosuvastatin 5 mg was inferior to daily rosuvastatin in keeping LDL-C below the target level, however, they have similar effect on hs-CRP.关键词
瑞舒伐他汀/间日给药/逐日给药/低密度脂蛋白胆固醇/超敏C反应蛋白Key words
rosuvastatin/alternate-day administration of drug/daily administration of drug/low-density lipoprotein cholesterol/high-sen-sitivity C-reactive protein分类
医药卫生引用本文复制引用
袁浩宇,王鹏,俞瑜..瑞舒伐他汀逐日给药与间日给药对血脂的影响[J].中国药业,2017,26(15):38-40,3.
