摘要
Abstract
Objective To compare the effect of rosuvastatin and atorvastatin on the levels of homocysteine ( Hcy ) and lipoprotein a in acute cerebral infarction ( ACI ) patients with cerebral hemorrhage. Methods Totally 100 ACI patients with cerebral hemorrhage in our hospital from March 2015 to October 2016 were selected and divided into the control group and the observation group by random num-ber table, 50 cases in each group. The two groups received routine treatment with lowering blood pressure, glucose control, antiplatelet aggregation, nourishment of nerve, improving cerebral circulation, maintaining normal metabolism, on this basis, the control group was given atorvastatin, while the observation group was given rosuvastatin. Results After treatment for 3 months, the levels of Hcy and lipoprotein a in two groups were significantly lower than those before treatment, and the observation group was significantly lower than the control group ( P < 0. 05 ) , the levels of TC, TG, LDL-C in the two groups were significantly lower than those before treatment, and the obser-vation group was significantly lower than the control group ( P < 0. 05 ) , but the levels of HDL-C in the two groups were higher than those before treatment, and the observation group was significantly higher than the control group ( P < 0. 05 ) . There was no statistical difference in the incidence of adverse drug reactions between two groups during treatment ( P > 0. 05 ) . Conclusion The effect of rosu-vastatin in treatment of ACI with cerebral hemorrhage is significantly better than that of atorvastatin, it can effectively adjust the levels of Hcy and lipoprotein a, control blood lipid smoothly, reduce risks of ACI with cerebral hemorrhage, and it has high safety.关键词
瑞舒伐他汀/阿托伐他汀/急性脑梗死/脑微出血/同型半胱氨酸/脂蛋白aKey words
rosuvastatin/atorvastatin/acute cerebral infarction/cerebral hemorrhage/homocysteine/lipoprotein a分类
医药卫生
