中国药业2017，Vol.26Issue(16)：6-8,3.DOI:10.3969/j.issn.1006-4931.2017.16.002
注射用牡荆素的冻干工艺参数优化
Optimization of Freeze-Drying Process Parameters of Vitexin for Injection
摘要
Abstract
Objective To optimize the freeze-drying process of vitexin for injection. Methods The parameters of freeze-drying process were optimized by taking the appearance,solubility,pH and moisture as indexes. Results The optimized freeze-drying process was as follows:pre freezing to +25 ℃ to -40 ℃,2 h;-40 ℃,3 h;the temperature was gradually increased to -20 ℃,and then gradually increased from -20 ℃ to 25 ℃. The sublimation drying process was about 26 h,and it was dried for about 5 h at 25 ℃. Conclusion By optimizing the parameters of freeze-drying process,the freeze-dried vitexin has smooth appearance and loose texture, it can quickly dissolve and disperse into clear solution in saline.关键词
注射用牡荆素/低共熔点/冷冻干燥/冻干曲线/工艺优化Key words
vitexin for injection/eutectic point/freeze-drying/freeze-drying curve/process optimization分类
化学化工引用本文复制引用
牛海军,李晓亮,邵旭,许亮,李光辉..注射用牡荆素的冻干工艺参数优化[J].中国药业,2017,26(16):6-8,3.基金项目
安徽省重大科技专项项目[15czz04082]. （）
