中国药业2017，Vol.26Issue(16)：9-12,4.DOI:10.3969/j.issn.1006-4931.2017.16.003
槲皮素对异烟肼联用利福平致大鼠肝损伤的防护作用
Protective Effects and Mechanisms of Quercetin on Hepatic Injury Induced by Isoniazid Combined with Rifampicin in Mice
摘要
Abstract
Objective To investigate the protective effect and mechanism of quercetin on liver injury induced by isoniazid(INH)combined with rifampicin (RFP) in rats. Methods Totally 50 male Wistar mice were fed with feed and water,and 1 week after adaptive feeding,the mice were randomly divided into blank control group,liver injury model group and quercetin low,middle and high dose groups,10 mice in each group. In addition to the blank control group,the mice in the other groups were given INH and RFP(each 75 mg/kg) per day for 4 weeks to prepare the animal models of liver injury in mice,and the blank control group was given equal volume of normal saline,2 h after giving INH and RFP,the low,middle and high dose groups were given low dosage,middle dosage and high dosage of quercetin(50,100,200 mg/kg),the blank control group and the liver injury model group were filled with equal volume of distilled water. The serum levels of AST,ALT and TBIL,liver index,contents of MDA,GSH,and SOD in liver were measured after 4 weeks of giving quercetin,and the hepatic pathological changes were also observed. Results Quercetin could reduce the liver index, the serum level of AST,ALT,TBIL and the content of MDA,raise the liver GSH content,promote the the activities of SOD in liver in mice. The degeneration and necrosis of liver tissue were relieved,and the pathological changes of liver tissue injury were alleviated. Conclusion Quercetin has the protective effect on the hepatotoxicity induced by INH combined with RFP in mice,and the mechanism may be related to the inhibition of lipid peroxidation of quercetin.关键词
槲皮素/大鼠/肝损伤/异烟肼/利福平/作用机制Key words
quercetin/mice/hepatotoxicity/isoniazid/rifampicin/mechanism of action分类
医药卫生引用本文复制引用
魏来,赵春景..槲皮素对异烟肼联用利福平致大鼠肝损伤的防护作用[J].中国药业,2017,26(16):9-12,4.基金项目
重庆市医学科研项目[2010-2-143]. （）
