中国药业2017，Vol.26Issue(16)：32-35,4.DOI:10.3969/j.issn.1006-4931.2017.16.010
不同全身麻醉方式对老年人术后认知功能障碍及复苏质量的影响
Effects of Different General Anesthesia Methods on Postoperative Cognitive Dysfunction and Recovery Quality in Elderly Patients
摘要
Abstract
Objective To compare the effect of different general anesthesia methods on postoperative cognitive dysfunction and recovery quality in elderly patients. Methods Totally 84 elderly patients were randomly divided into group P,group S and group C. After con-ventional intravenous induction,anesthesia was maintained by propofol,sevoflurane,propofol combined with sevoflurane in group P,group S and group C,respectively,while intravenous injection of remifentanil. The extubation time,recovery time,the incidence of agitation were observed. The plasma concentrations of IL-6 and S100β were determined 1 d before operation(T0),at the end of the operation(T1),on the first day after operation(T2),on the third day after operation(T3). Postoperative cognitive dysfunction was assessed by min-mental state examination(MMSE)at T0,T2,T3. The incidence of hypotension and bradycardia during operation and the incidence of hypoxemia, analgesia,nausea and vomiting after operation were recorded. Results Compared with group P and group C,the extubation time and recovery time were longer and the incidence of agitation was higher in group S( P < 0. 05). The level of S100β was higher in group S than those in group P and group C at T2( P < 0. 05). The level of S100β was highest at T1 in group P and group C at T1 ( P < 0. 05),while the levels of S100β was higher at T1 and T2 than those at T3 and T4 in group S( P < 0. 05). There was no significant difference among the three groups in the MMSE score and the incidence of POCD( P > 0. 05). The incidence of hypotension was high-est in group S( P < 0. 05). Compared with group S and group C,the incidence of bradycardia was higher but the incidence of nausea and vomiting was lower in group P( P < 0. 05). Conclusion General anesthesia is a suitable anesthesia method for elderly patients, which has the advantages of quick recovery,short duration of central nervous system damage and less complications.关键词
静脉麻醉/吸入麻醉/静吸复合麻醉/术后认知功能障碍/复苏质量/老年Key words
intravenous anesthesia/inhalation anesthesia/balance anesthesia/postoperative cognitive dysfunction/recovery quality/elderly分类
医药卫生引用本文复制引用
罗耀文,徐明禹,董心童,袁瑞霞,詹美俊,张雪萍..不同全身麻醉方式对老年人术后认知功能障碍及复苏质量的影响[J].中国药业,2017,26(16):32-35,4.基金项目
广东省深圳市科技计划项目[JCYJ20140416122812032]. （）
