中国肿瘤生物治疗杂志2017，Vol.24Issue(7)：693-699,7.DOI:10.3872/j.issn.1007-385x.2017.07.001
从肿瘤微环境角度解析肿瘤免疫治疗的现状与未来
Analysis of present situation and future of cancer immunotherapy from the perspective of tumor microenvironment
摘要
Abstract
The studies of immune checkpoint represented by programmed death 1 (PD-1) have pushed cancer immunotherapy to a climax,which implies that modulating the negative immune regulatory pathway could create an effective immunotherapy strategy.Meanwhile,the tumor microenvironment plays an important role in suppressing or enhancing immune response.Therefore,it will provide new immunotherapy strategy,and make foundation for individualized precision medicine,based on the mechanism of interation between immune response and tumor microenvironment.This review summarized the research progress of cancer immunotherapy from the perspective of how the tumor microenvironment affects immune response,and aimed to propose a new strategy for cancer immunotherapy.关键词
肿瘤微环境/肿瘤免疫治疗/免疫检查点Key words
tumor microenvironment/cancer immunotherapy/immune checkpoint分类
医药卫生引用本文复制引用
於宇,崔久嵬..从肿瘤微环境角度解析肿瘤免疫治疗的现状与未来[J].中国肿瘤生物治疗杂志,2017,24(7):693-699,7.基金项目
国家自然科学基金资助项目(No.81672275),国家卫计委重大疾病防治科技行动计划资助项目(No.2016ZX-07-002).Project supported by the National Natural Science Foundation of China (No.81672275),and the Technology Action Plan on Prevention and Treatment of Major Diseases of the National Health and Family Planning Commission of China(No.2016ZX-07-002) （No.81672275）
