中国中西医结合外科杂志2017，Vol.23Issue(4)：339-343,5.DOI:10.3969/j.issn.1007-6948.2017.04.001
"清法"对湿热毒盛糖尿病足坏疽急性创面局部炎症因子的影响
Effect of Clearing Method on Inflammatory Factors in Acute Wounds Fluid of Diabetic Foot Gangrene with Dampness Heat Toxic Syndrome
摘要
Abstract
Objective To explore the mechanism of "Clearing Method" in treatment of the patients with di?abetic foot gangrene and dampness heat toxic syndrome in the acute phase. Methods Eighty patients with dia?betic foot gangrene and acute dampness heat toxic syndrome (Wagner 4 level) were randomly divided into"Clear?ing Method"treatment group (n=40) and western medicine control group (n=40). All patients received basic treat?ment. In addition, the patients in treatment group received Xi Jiuyi's prescriptions—Chenlanhua granules, San?huangxiaoyan granules and Qufuqingjin debridement for dispelling putridity and clearing sinew. The patients in control group experienced surgical debridement. The effectiveness of wound healing was examined 2 weeks and 4 weeks after debridement. At the same time, wound fluids were collected before debridement, and on the 1st, 7th, 14th and 28th days after debridement. The levels of tumor necrosis factor-a (TNF-a), interleukin (IL)-6 and intercellular adhesion molecule (ICAM)-1 in the acute wound fluid were assessed to evaluate the severity of the was (132551.2678±69467.8635) pg/mL,(120472.4313±85215.3433)pg/mL,(99812.8301±78081.8376)pg/mLl,(90345.3259±74386.5024)pg/mL and(74491.4063±61588.1498)pg/mL before debridement and on the 1st, 7th, 14th and 28th days after debridement, while IL-6 was (67583.2999 ± 26329.1573) pg/mL, (58222.3824 ± 25733.9665) pg/mL,(55535.6338 ± 22380.2142) pg/mL, (50220.2076 ± 19794.5744) pg/mL and (43185.8820±20904.6316)pg/mL, ICAM-1 was(6399.4579±2833.9183)pg/mL,(5811.0572±2792.3656)pg/mL, (4722.0211 ± 2200.8927) pg/mL, (4231.5074 ± 1988.8923) pg/mL, (3407.6614 ± 2031.0389) pg/mL respec?tively. The levels of three inflammatory factors in each group at each time after debridement were significantly lower than those before debridement, while the levels of TNF-α and IL-6 in treatment group at each time after debridement were lower than those in control group. Conclusion "Clearing Method" can alleviate local in?flammatory responses by reducing the level of inflammatory factors in acute wounds and promote wound healing in diabetic foot gangrene with dampness heat toxic syndrome.关键词
糖尿病足/清法/渗出液/炎症因子/湿热毒盛证Key words
Diabetic foot/clearing method/wound fluid/inflammatory factors/dampness heat toxic syn⁃drome分类
医药卫生引用本文复制引用
杨沁彤,张国奇,方豫东,赵普庆,曹烨民,王伟灵,尹凌峰,徐洪涛,胡高武,杨建飞.."清法"对湿热毒盛糖尿病足坏疽急性创面局部炎症因子的影响[J].中国中西医结合外科杂志,2017,23(4):339-343,5.基金项目
上海市科委中医引导类资助项目(13401905600) （13401905600）
