中国中西医结合外科杂志2017，Vol.23Issue(4)：353-355,3.DOI:10.3969/j.issn.1007-6948.2017.04.004
Caspase-3蛋白在结直肠癌组织中的表达及临床意义
The Clinical Significance of Caspase-3 Expression in Colorectal Cancer
曹斌校1
作者信息
- 1. 浙江省奉化市人民医院普外一科 宁波 315500
- 折叠
摘要
Abstract
Objective To assess the clinical significance of Caspase-3 expression in colorectal cancer. Methods Forty eight patients with colorectal cancer were included in this study. The Caspase-3 expression was assayed by immunohistochemistry method for the cancer tissue and corresponding para-cancer tissue. The associations between Casepase-3 expression and clinical characteristics, prognosis were evaluated. Results Caspase-3 was mainly expressed in cytoplasm with the positive rate of 27.08% in cancer tissue and 58.33% in normal colorectal tissue. The positive rate in normal colorectal tissue was significant higher than that of cancer tissue with statistical difference(P<0.05). Caspase-3 expression was associated with the tumor stage(P<0.05) and pathology grading (P<0.05). The disease free survival for positive and negative patients were 32.4 and 24.8 months with statistical difference HR=1.67, 95%CI:0.68-3.89(P>0.05). Conclusion The expression rate of Caspase-3 protein in human colorectal cancer tissue is low, which may be related to the occurrence and develop?ment of colorectal cancer.关键词
结直肠癌/含半胱氨酸的天冬氨酸蛋白水解酶/免疫组织化学/临床特征/生存期Key words
Colorectal cancer/Caspase-3/immunohistochemistry/clinical characteristics/survival分类
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曹斌校..Caspase-3蛋白在结直肠癌组织中的表达及临床意义[J].中国中西医结合外科杂志,2017,23(4):353-355,3.
