中国卒中杂志2017，Vol.12Issue(8)：677-681,5.DOI:10.3969/j.issn.1673-5765.2017.08.004
糖调节异常对缺血性卒中患者脑组织毛细血管渗透性和出血转化的影响
Effects of Abnormal Glucose Regulation on the Capillary Permeability and Hemorrhagic Transformation of Ischemic Stroke
摘要
Abstract
Objective To observe the feature of capillary permeability in ischemic tissue of patients with acute ischemic stroke (AIS), and analyze the effects of abnormal glucose regulation on the capillary permeability and hemorrhagic transformation of ischemic brain tissue. Methods Patients with AIS were enrolled into study consecutively. Oral glucose tolerance test (OGTT) was performed to diagnose the abnormal glucose regulation in patients with acute ischemic stroke. Computer tomography (CT) perfusion imaging and permeability surface (PS) color map was performed to measure the capillary permeability of ischemic brain tissue. Results A total of 420 cases with AIS were recruited during study period. The capillary permeability of brain tissue with hypoperfusion in patients with diabetes mellitus increased significantly compared with patients with normal glucose regulation (P=0.006). Higher fasting glucose concentration at (14±3) days after onset was identified as an independent risk factor for hemorrhagic transformation after ischemic stroke [odd ratios 1.448, 95% confidence interval (1.017-2.061),P=0.04]. Conclusion The capillary permeability of ischemic brain tissue increased significantly in patients with diabetes mellitus. It was possible that abnormal glucose regulation increased the capillary permeability of ischemic brain tissue, and consequently increased the risk of hemorrhagic transformation.关键词
缺血性卒中/糖调节异常/毛细血管渗透性/出血转化Key words
Ischemic stroke/Abnormal glucose regulation/Capillary permeability/Hemorrhagic transformation引用本文复制引用
贾茜,赵性泉,王辉,郑华光,王伊龙,王拥军..糖调节异常对缺血性卒中患者脑组织毛细血管渗透性和出血转化的影响[J].中国卒中杂志,2017,12(8):677-681,5.基金项目
科技部国家重点研发项目(2011BAI08B02,2013BAI09B14,2015BAI12B04) （2011BAI08B02,2013BAI09B14,2015BAI12B04）
