中医药学报2017，Vol.45Issue(3)：45-47,3.
大承气汤对多器官功能障碍综合征大鼠肠源性内毒素血症的疗效机制
Therapy Mechanism of Dachengqi Decoction in Rats with Multiple Organ Dysfunction Caused by Intestinal Endotoxemia
摘要
Abstract
Objective:To discuss the therapy mechanism of Dachengqi Decoction in treating intestinal endotoxemia (IETM).Method:60 SD rats were randomly divided into 5 groups:the blank control group(group B),the model group (group M),Dachengqi Decoction group(group D),Ampicillin group(group A) and lactulose group(group L).MODS models were made by intraperitoneal injection of asepsis Zymosan A.Normal saline,Dachengqi Decoction,Ampicillinum and lactulose were given to the rats through intragastric administration twice a day after the models were made.Mter 48 hours,the endotoxin level of portal vein blood and aortaventrails blood were tested;TNFa,IL-1 and IL-6 in the serum were tested through radioimmunity method,and SOD and LPO were tested through substrate method.Results:1.Group D can reduce the endotoxin level in IETM rats significantly,compared to group A and group L (P ＜ 0.05).2.The level of TNFa and IL-1 reduced significantly in group D compared to the other groups(P ＜0.05).The level of IL-6 reduced significantly in group D and the group L(P ＜ 0.05).3.Group D could raise SOD level and reduce LPO level significantly compared to the other groups (P ＜ 0.05).Conclusion:Dachengqi Decoction can reduce the body injury caused by endotoxin in IETM rats by reducing the level of TNFa,IL-1 and IL-6.关键词
大承气汤/肠源性内毒素血症/多器官功能障碍综合征Key words
Dachengqi Decoction/Intestinal endotoxemia(IETM)/Multiple organ dysfunction分类
医药卫生引用本文复制引用
孙晓龙,李承,赵振宇,王萌影,陈静,王旭,杨波,李响..大承气汤对多器官功能障碍综合征大鼠肠源性内毒素血症的疗效机制[J].中医药学报,2017,45(3):45-47,3.基金项目
黑龙江省自然科学基金面上项目(D200937) （D200937）
