安徽农业科学2017，Vol.45Issue(22)：75-77,3.
不同制剂方式对诺氟沙星在鳗鲡中药动学的影响
Effects of Different Formulation Ways on Pharmacokinetics of Norfloxacin in Anguilla japonica
摘要
Abstract
[Objective] To explore the influences of formulation ways on pharmacokinetics of drugs in aquatic animals.[Method] Four formulations (NP,NB,NN and NL) of norfloxacin (NFX) in Anguilla japonica were studied by a single oral dose of 30 mg/kg NFX.The content of NFX in plasma of eels was determined by UPLC-MS and computed by non-compartment model.[Result] Pharmacokinetics parameters of NP,NB,NN and NL showed that Cmax were 1.273,1.073,0.616 and 0.094 mg/L after single drug administration 3 or 4 h;T1/2 were 15.267,24.887,33.041 and 25.891 h respectively;AUC of NP was the maximum,being 22.670 mg/(L·h).NP:NB:NN:NL=100%:99%:63%:13%.[Conclusion]Different formulation ways of drugs had greater effects on the absorption and bioavailability of medicine in aquatic animals.关键词
诺氟沙星/日本鳗鲡/药代动力学/制剂方式Key words
Norfloxacin/Anguilla japonica/Pharmacokinetics/Sormulation ways分类
农业科技引用本文复制引用
贾雪卿,范红照,湛嘉,朱远芳,黄利强,林茂..不同制剂方式对诺氟沙星在鳗鲡中药动学的影响[J].安徽农业科学,2017,45(22):75-77,3.基金项目
公益性行业(农业)科研专项(201203085) （农业）
海洋经济创新发展区域示范项目(16PZY002SF18) （16PZY002SF18）
福建省自然科学基金项目(2014J01129). （2014J01129）
