波谱学杂志2017，Vol.34Issue(3)：275-282,8.DOI:10.11938/cjmr20162553
1.5T磁共振化学交换饱和转移成像的影响因素分析
Factors Affecting Chemical Exchange Saturation Transfer Imaging on 1.5T Clinical MRI Scanners
摘要
Abstract
Acquisition parameters for chemical exchange saturation transfer (CEST) imaging were optimized on a GE Signa HDe 1.5 T magnetic resonance imaging (MRI) scanner with phantoms and clinical cases. The effects of matrix size, number of averages (NEX) and flip angles on the quality of CEST images were assessed. It was shown that the signal-to-noise ratio (SNR) of the CEST images acquired on the 1.5 T scanner was relatively low, and the stability and uniformity of the B0 field affected the outcome significantly. Reducing matrix size and increasing NEX improved the SNR of the CEST images. Optimal flip angle for magnetization transfer was found to be 105?. With a NEX of 2, usable Z spectra could be obtained. The Z spectra indicated that, with the saturation pulse frequency centered at -294 ~ -194 Hz, signal differences could be observed for 30% Glu, I320, H2O, and Cr. Maximal signal differences were observed when the saturation pulse applied at -244 ~ -214 Hz. Amide proton transfer (APT) imaging on patients showed that 25 cases of brain tumor had high CEST signals, 12 cases of cerebral infarction had low CEST signals. It was therefore possible to differentiate brain tumor from infarction with CEST imaging. There were also 12 cases which failed due to long acquisition time, patient movements, and temperature changes in the scanner room.关键词
磁共振成像(MRI)/化学交换饱和转移(CEST)/酰胺质子转移(APT)/酸碱度Key words
magnetic resonance imaging (MRI)/chemical exchange saturation transfer (CEST)/amide proton transfer (APT)/pH分类
数理科学引用本文复制引用
杨永贵,陈忠,蔡聪波,郭岗..1.5T磁共振化学交换饱和转移成像的影响因素分析[J].波谱学杂志,2017,34(3):275-282,8.基金项目
厦门市科技局科技惠民计划资助项目(3502Z20144052) （3502Z20144052）
卫生部福建省卫生教育联合攻关计划资助项目(WKJ-FJ-05). （WKJ-FJ-05）
