波谱学杂志2017，Vol.34Issue(3)：302-310,9.DOI:10.11938/cjmr20172558
新型Gd基T2造影剂的制备和应用
A New Gd-Based T2-Weighted Magnetic Resonance Imaging Contrast Agent: Preparation and Application in Stem Cell Imaging
摘要
Abstract
We synthesized TPP-Lys(Acp-DOTA-Gd)-COOH (Gd-DOTA-TPP) as a novel T2-weighted MRI contrast agent, and used it to label human mesenchymal stem cells (hMSCs) via electroporation. hMSCs labeled with Gd-DOTA-TPP presented a rather dark T2-weighted image at a cellular Gd content of about 9×109 Gd/cell. The labeled cells were syringe-injected into a mouse brain with defined cell numbers followed by T2-weighted MRI on an 11.7 T system, which yield an in vivo imaging sensitivity of about 103 cells.关键词
磁共振成像(MRI)/造影剂/人源脐带间充质干细胞(hMSCs)/TPP-Lys(Acp-DOTA-Gd)-COOH(Gd-DOTA-TPP)/灵敏度Key words
magnetic resonance imaging (MRI)/contrast agent/human mesenchymal stem cells (hMSCs)/TPP-Lys(Acp-DOTA-Gd)-COOH (Gd-DOTA-TPP)/sensitivity分类
数理科学引用本文复制引用
张艳辉,张宏岩,张海禄,张朋利,蒋海珍,邓宗武,谭波..新型Gd基T2造影剂的制备和应用[J].波谱学杂志,2017,34(3):302-310,9.基金项目
国家自然科学基金资助项目(31371010). （31371010）
