长春中医药大学学报2017，Vol.33Issue(4)：530-533,4.DOI:10.13463/j.cnki.cczyy.2017.04.005
玉米须总皂苷对非酒精性脂肪肝病大鼠肝脏PPARγ 表达的影响
Effect of Saponin extracted from Zea Mays L (ZMLS) to PPARγ of liver in non alcohol fatty liver disease rats
摘要
Abstract
Objective To investigate whether Zea Mays L (ZMLS) has therapeutic effect and its mechanism of liver in non alcohol fatty liver disease (NAFLD) rats. Methods After feeding adaptation 10 d, the same batch SD rats (60) were randomly divided into normal group, model group and ZMLS treatment group (n=20), after successful built non-alcoholic fatty liver disease model, the normal group and model group were given 1 g/kg/d normal saline, ZMLS group was received 4 mg/(kg. d)orally, after treatment 4 and 8 weeks, the rats were sacrificed and detected biochemical and liver PPARγ expression. Results Compared with normal group, the model group in AST, ALT, IL-1, IL-6, FBG, TG and FFA were increased significantly (P<0.05), FINS was decreased significantly (P<0.05), after 4 weeks of treatment, AST, ALT , IL-1, IL-6, FBG, TG and FFA were decreased (P<0.05), FINS was increased significantly (P<0.05); After 8 weeks of treatment, AST, ALT, IL-1, IL-6, FBG, TG and FFA were further reduced关键词
玉米须总皂苷/肝功能/游离脂肪酸/过氧化物酶增殖物活化受体γ/非酒精性脂肪肝病Key words
ZMLS/liver function/free fatty acids/PPARγ/non alcohol fatty liver disease分类
医药卫生引用本文复制引用
余渊,程杰..玉米须总皂苷对非酒精性脂肪肝病大鼠肝脏PPARγ 表达的影响[J].长春中医药大学学报,2017,33(4):530-533,4.基金项目
湖北省科技厅立项 黄石市爱康医院自筹项目"玉米须总皂苷对非酒精性脂肪肝病的治疗作用"(2015HS036). （2015HS036）
