国际医药卫生导报2017，Vol.23Issue(15)：2319-2321,3.DOI:10.3760/cma.j.issn.1007-1245.2017.15.002
甘氨酸对烧伤大鼠失控炎症反应的调控作用及机制研究探讨
Glycine in regulation of inflammatory response in burn rats and its mechanism
摘要
Abstract
Objective To explore glycine in the regulation of inflammatory response in burn rats and its mechanism.Methods Glycine in the regulation of inflammatory response in burn rats was evaluated analyzing the Ca2+ concentration in the rats' peritoneal macrophages.Results 3,6,12,and 24 h,there were statistical differences in the plasma LPS levels between the burn and sepsis group and the other three groups (all P ＜ 0.05).There were statistical difference in the plasma level of TNF-α between the burn and sepsis group and the burn group at 3h (P ＜ 0.05) and were between the burn and sepsis group and the other three groups at 6 and 12h and between the burn and sepsis and treated by glutamine group and the other 3 groups at 24h (P ＜ 0.05).There were no statistical differences in the plasma level of IL-10 between the 4 groups at 3h (all P＞ 0.05) and were between the burn and sepsis and treated by glycine group and the other 3 groups at 6h and between the burn and sepsis and treated by glycine group and the burn and sepsis and treated by glutamine group (all P＜ 0.05).Conclusion Gln and Gly have anti-inflammatory and anti-sepsis effects in clinic and can reduce the plasma levels of LPS and TNF-α and promote the secretion of IL-10 in burn rats with sepsis.关键词
烧伤大鼠/甘氨酸/内毒素/炎症反应/作用机制Key words
Burn rats/Glycine/Endotoxin/Inflammatory response/Mechanism引用本文复制引用
林泽鹏,杨荣华,阮树斌,林颜,张凤刚,熊想莲,陈晓东..甘氨酸对烧伤大鼠失控炎症反应的调控作用及机制研究探讨[J].国际医药卫生导报,2017,23(15):2319-2321,3.基金项目
国家自然基金资助(81671970)Project Supported by National Natural Fund (81671970) （81671970）
