国际医药卫生导报2017，Vol.23Issue(16)：2529-2532,4.DOI:10.3760/cma.j.issn.1007-1245.2017.16.008
结核病传播链分子流行病学研究的病例选择方法初探
Primary study on case selection for molecular epidemiology analysis of tuberculosis transmission chain
摘要
Abstract
Objective To assess the performance of case selection way based on case residence for molecular epidemiology analysis of tuberculosis transmission chain theoretically.Methods The data of cases with tuberculosis,from which 9 234 strains M.tuberculosis were isolated,were extracted from Mycobacteria biobank of Guangzhou in our hospital.In the case of assumed transmission relationship based on the case residence,the time intervals of disease occurring and combinations of gender and age in per transmission chain were analyzed.Results According to rural administrative divisions (including county,town,village,and group) and urban administrative zoning (including city,district,community,and street),a total of 387 presumed tuberculosis transmission chains were found.The transmission chains contained 2-5 cases were major and their number were 210,100,35,and 23 respectively.The numbers of chains contained 6,7,8,11,and 12 cases were 6,7,4,1,and 1 respectively.From case residence,the transmission chains forming in the same village and street were dominated in rural administrative divisions and urban administrative zoning and accounted for 89.39％ (59/66) of rural transmission chains and 89.10％ (286/321) of rural transmission chains.As to the time intervals of disease occurring in per transmission chain,there were the following cases:6 months,1 year,1 year and a half,2 years,2 years and a half,3 years,and more than 3 years.The numbers of the transmission chains were 131,81,59,59,50,6,and 1 in the above cases of time intervals.The numbers of the transmission chains of different sex-across one age group,same sex-same age group,different sex-across two age group,different sex-same age group,same sexacross one age group,same sex-across two age group,and different sex-across three age group were 94,69,69,67,59,28,and 1 if cases were regarded as juvenile (＜1 5 years old),youth (15-44 years old),middle age (45-64 years old),and old age (≥65 years old).Conclusion The cases gained by the patients' residence is in line with the current theory of tuberculosis transmission,and is feasible for study on molecular epidemiology of tuberculosis transmission chain.关键词
结核病/传播链/分子流行病学Key words
Tuberculosis/Transmission chain/Molecular epidemiology引用本文复制引用
吴玲,邝浩斌,刘志辉,王楠,雷杰,竺澎波,孟繁荣,谢贝,杨瑜,牛群,谭守勇..结核病传播链分子流行病学研究的病例选择方法初探[J].国际医药卫生导报,2017,23(16):2529-2532,4.基金项目
Medical Science and Technology Research Fund Project of Guangdong (A2016149) （A2016149）
Scientific and Technological Project of Guangzhou (155700012) （155700012）
Scientific and Technological Major Project of Guangzhou Pharmaceutical and Health (20151A031002)广东省医学科学技术研究基金项目(A2016149) （20151A031002）
广州市科技计划项目(155700012) （155700012）
广州市医药卫生科技重大项目(20151A031002) （20151A031002）
