广西医学2017，Vol.39Issue(8)：1112-1118,7.DOI:10.11675/j.issn.0253-4304.2017.08.02
美沙拉嗪联合双歧杆菌三联活菌散治疗溃疡性结肠炎临床疗效的Meta分析
Clinical efficacy of mesalazine combined with bifico for treatment of ulcerative colitis:a Meta-analysis
摘要
Abstract
Objective To evaluate the clinical efficacy of mesalazine combined with bifico for the treatment of ulcerative colitis(UC).Methods The databases of computer retrieve included Cochrane,PubMed,EMbase,CBM,CNKI and VIP database.Randomized controlled trials(RCTs) about mesalazine combined with bifico for the treatment of UC were enrolled.The quality of literatures was assessed after screening.Meta-analysis was conducted using RevMan 5.3 software.Results Thirty-four RCTs consisting of 2 390 patients were included.The results of Meta-analysis showed that the total effective rate of the combination group(mesalazine combined with bifico) was higher than that of the single group(mesalazine only)(P<0.05).After treatment,the descent levels of serum tumor necrosis factor-α,interleukin-10,C-reactive protein,clinical symptom score and endoscopic score were higher in the combination group compared to the single group(all P<0.05).Conclusion Oral administration of mesalazine and bifico for UC can significantly improve the clinical efficacy and reduce the levels of inflammatory indicators.关键词
溃疡性结肠炎/美沙拉嗪/双歧杆菌三联活菌散/临床疗效/荟萃分析Key words
Ulcerative colitis/Mesalazine/Bifico/Clinical efficacy/Meta-analysis分类
医药卫生引用本文复制引用
韩李春,叶自亮,吕晓丹,陈兰,詹灵凌,吕小平..美沙拉嗪联合双歧杆菌三联活菌散治疗溃疡性结肠炎临床疗效的Meta分析[J].广西医学,2017,39(8):1112-1118,7.基金项目
国家自然科学基金(81460114) （81460114）
广西留学回国人员科学基金(桂科回0832009) （桂科回0832009）
广西中医药科技专项课题(GZPT1238) （GZPT1238）
广西中医药科技专项课题(GZLC14-28) （GZLC14-28）
