工业微生物2017，Vol.47Issue(4)：19-23,5.DOI:10.3969/j.issn.1001-6678.2017.04.003
富硒双歧杆菌缓解5-FU导致的化疗性肠粘膜炎的药效学研究
Preventative effects of selenium-enriched Bifdobacterium Longum on 5-fluorouracil-induced intestinal mucositis in mice
摘要
Abstract
In order to evaluate the effects of selenium-enriched Bifidobacterium longum (Se-B.longum) on 5-FU-induced intestinal mucositis in healthy mice,Se-B.longum (Se 0.3 mg/kg BW,1×106 bacteria/mice) was administered to mice for 6 days before administration of 5-FU (250 mg/kg,single dose).Body weight loss,liver index,spleen index,diarrhea and impaired small intestine induced by 5-FU was significantly alleviated by Se-B.longum (P<0.05).Se-B.longum (Se 0.3 mg/kg BW,1×106 bacteria/mice) significantly decreased mortality induced by 5-FU (300 mg/kg,single dose).As a result,Se-B.longum could relieve the intestinal mucositis and the mortality induced by 5-FU in normal mice.关键词
富硒长双歧杆菌/5-FU/化疗性肠粘膜炎Key words
selenium-enriched Bifidobacterium longum/5-FU/chemotherapy-induced mucositis引用本文复制引用
邱玉爽,纪瑞,邵雷,陈代杰,谭俊..富硒双歧杆菌缓解5-FU导致的化疗性肠粘膜炎的药效学研究[J].工业微生物,2017,47(4):19-23,5.基金项目
国家"重大新药创制"科技重大专项(No.2013ZX09301302,No.2014ZX09507009-025) （No.2013ZX09301302,No.2014ZX09507009-025）
国家自然科学基金(No.81573329) （No.81573329）
国家青年科学基金(No.81603004) （No.81603004）
上海市优秀技术带头人计划(17XD1423200) （17XD1423200）
上海市自然科学基金(16ZR1435400). （16ZR1435400）
