李刚 1宋佳 1庞咪 1马明明 1徐长水 1张杰文1
作者信息
- 1. 河南省人民医院暨郑州大学人民医院、河南大学人民医院神经内科,河南 郑州 450003
- 折叠
摘要
Abstract
Objective To study the clinical,electrophysiological features and prognosis of the Miller-Fisher Syndrom (MFS).Method A total of 9 elderly patients with MFS were retrospective observed according to clinical manifestations,auxiliary examination,treatment and prognosis.Result Among this groups,male female ratio was 4:5,the mean age was 68.3±4.1 years,the mean course was 19.2±9.9 days,onset in spring and winter was predominant,3 cases were involved with respiratory tract infection;As the initial symptom,there were dizziness,headache,drooping eyelids,diplopia,walking instability and numbness and weakness of limbs,the mean time of onset to peak was 2.7±2.8 days;All the patients was charactered with the ophthalmoplegia,taxia and areflexia,there are five cases with ophthalmalgia,two cases with intraocular muscles,four cases with facial nerve damaged,three cases with glossopharyngeal and vagus nerve damaged,three cases with decreased myodynamia,six cases with superficial loss or disappearance of the distal extremities,three cases with autonomic nerve involvement;Five cases with anti-GQ1b antibody positive,six cases are of obvious albuminocytolgoic dissociation of cerebrospinal fluid,seven cases with damage by the electromyography,and five cases with sensory nerve conduction involvement;The immunoglobulin and/or methylprednisolone therapy are for all cases,the headache,ophthalmalgia,numbness of the limbs were improved earliest,and ophthalmoplegia,taxia began to improve at an average of 2.5±1.5 days、6.3±3.8 days respectively,the areflexia was no improvement at 2~3 weeks when discharged from hospital.The average time of staying hospital was 15.0±4.6 days,and they all improved at discharge.Conclusion The clinical manifestations are diverse of the elderly with MFS.It is mainly involved in sensory nerve conduction of Electromyography.Serum anti GQ1b antibodies are useful for the diagnosis.And it is improved after immunoglobulin and/or methylprednisolone treatment.关键词
Miller-Fisher综合征/老年/临床/神经电生理Key words
Miller-Fisher Syndrom/the elderly/Clinical/Electrophysiological分类
医药卫生
