检验医学与临床2017，Vol.14Issue(16)：2355-2358,4.DOI:10.3969/j.issn.1672-9455.2017.16.009
新疆地区不同民族间萎缩性胃炎、胃癌患者血清胃蛋白酶原、胃泌素-17及幽门螺杆菌感染相关性分析
Correlation analysis of serum pepsinogen,gastrin-17 and Helicobacter pyloriinfection between atrophic gastritis and gastric cancer among different nationalities in Xinjiang
摘要
Abstract
Objective To investigate correlation between atrophic gastritis(AG),gastric disease and serum pepsinogen(PG),PGR(PGⅠ/PGⅡ ratio),gastrin-17(G-17) and Helicobacter pylori(Hp) infection among different nationalities in Xinjiang region,and analyze their feasibility as a screening index of AG and gastric cancer.Methods A total of 310 cases were selected in the department of gastroenterology in our hospital from May 2015 to May 2016,and their gastroscopy met the criteria for inclusion in this study.They were divided into control group(mild and non AG) with 66 cases,AG group with 126 cases,and gastric cancer group with 118 cases according to the results of pathological examination.The levels of fasting serum PGⅠ,PGⅡ and G-17 were detected by ELISA method,and the PGR value was calculated;the Hp was detected with urea breath test.The serum levels of PGⅠ,PGR and G-17 were compared among different groups and different nationalities,the Hp infections and the optimal critical values of PGⅠ,PGR and G-17 in the diagnosis of AG were compared among different nationalities of different groups.Results The levels of PGⅠ and PGR from lowest to highest were gastric cancer group,AG group,control group,the levels of G-17 from lowest to highest were AG group,control group,gastric cancer group,the difference among groups was statistically significant(P<0.05).The levels of serum PGⅠ and PGR among different nationalities in AG group and gastric cancer group were compared,and those of Kazak<Uygur<Han(P<0.05);the level of serum G-17 among different nationalities in AG group were compared,and those of Kazak<Uygur<Han(P<0.05).The level of serum G-17 among different nationalities in gastric cancer group were compared,and those of Han<Uygur and Kazak(P<0.05);there was no difference between that of Uygur and Kazak(P>0.05).The infection rate of Hp among different nationalities in gastric cancer group and AG groups was higher than that of control group(P<0.05),the infection rate of Hp in different nationalities was no significant difference in each group(P>0.05).The optimal critical values of PGⅠ,PGR and G-17 in diagnosis of atrophic gastritis were obtained according to the receiver operating characteristic(ROC) curve.Conclusion The levels of serum PG,PGR,G-17 and the Hp infection can be used as the serological markers for screening AG and gastric cancer in Xinjiang region.关键词
萎缩性胃炎/胃癌/胃蛋白酶原/胃泌素-17/幽门螺杆菌Key words
atrophic gastritis/gastric cancer/pepsinogen/gastrin-17/Helicobacter pylori分类
社会科学引用本文复制引用
柯月,梁灿灿,纪文静,丁永年..新疆地区不同民族间萎缩性胃炎、胃癌患者血清胃蛋白酶原、胃泌素-17及幽门螺杆菌感染相关性分析[J].检验医学与临床,2017,14(16):2355-2358,4.基金项目
新疆维吾尔自治区地方病分子生物学实验室开放课题资助项目(XJDX0208-2013-06). （XJDX0208-2013-06）
