摘要
Abstract
Objective To investigate the value of peripheral blood cytokines in the diagnosis of chronic hepatitis B.Methods From February 2014 to February 2015,34 patients with chronic hepatitis B were selected as the study group,and 34 healthy persons who came to the hospital for the same period were selected as healthy control group,all patients underwent blood related examination and cell culture,and the study group was treated with Compound Embryonic Bovine Liver Extract Tablets and entecavir Cave.The levels of cytokines in the patients before and after treatment were compared between the two groups.Results The level of IL-4 in the study group was higher than that in the healthy control group,and the level of IFN-γ was lower than that of the healthy control group(P<0.05);there was no significant difference between the two groups in IL-10 levels(P>0.05).In the study group,the level of IL-4 was lower than that before treatment,IFN-γ levels were higher than before treatment(P<0.05);there was no significant difference in the level of IL-10 before and after treatment in the study group(P>0.05).In the study group,the positive rate of IL-4 in the HBeAg positive group was higher than that in the HBeAg negative group(P<0.05),there was no significant difference in the level of IL-10 between the HBeAg positive group and the HBeAg negative group(P>0.05).The levels of AST,ALT,Alb and TBiL in the study group were better than those before treatment(P<0.05).Conclusion Peripheral blood cytokines can effectively define the balance of Th1/Th2 lymphocyte immune response in T cells,and play an important role in judging the therapeutic effect of chronic hepatitis B.关键词
外周血细胞因子/慢性乙型肝炎/疗效判断Key words
peripheral blood cytokines/chronic hepatitis B/efficacy evaluation分类
社会科学
