检验医学与临床2017，Vol.14Issue(16)：2411-2413,3.DOI:10.3969/j.issn.1672-9455.2017.16.029
重组人粒细胞集落刺激因子联合抗菌药物对糖尿病足感染患者VEGF及Flt-1的影响
Effect of rhG-CSF injection combined with systemic antibacterials on VEGF and Flt-1 in patients with diabetic foot infection
赵汉儒1
作者信息
- 1. 海南省儋州市第一人民医院内分泌科 571700
- 折叠
摘要
Abstract
Objective To investigate the effects of recombinant human granulocyte colony stimulating factor(rhG-CSF) injection combined with systemic antibacterials on VEGF and its receptor Flt-1 in patients with diabetic foot infection(DFI).Methods A total of 78 cases of patients with DFI in our hospital were selected from July 2015 to July 2016,and were randomly divided into two groups,39 cases in each group.The control group received routine treatment and intravenous drip of levofloxacin,and the observation group was given subcutaneous injection of rhG-CSF on the basis of the control group.After 30 days of treatment,the therapeutic effect and serum levels of VEGF and Flt-1 in two groups were observed.Results After treatment,the total effective rate of observation group was significantly higher than that of the control group(P<0.05);the wound area was significantly lower than the control group(P<0.05);and the difference of granulation growth days and epithelium formation days between the two groups was statistically significant(P<0.05).The levels of VEGF and Flt-1 in the control group after the treatment showed no significant difference when compared with that before the treatment(P>0.05),but the difference in the observation grop was statistically significant(P<0.05).The levels of VEGF and Flt-1 in the observation group were significantly higher than those in the control group(P<0.05).Conclusion The combination of rhG-CSF and systemic antibacterials can promote the expression of Flt-1 and VEGF,shorten the days of epithelial cell formation and reduce the wound area,which is effective in the treatment of DFI.关键词
糖尿病足/感染/重组人粒细胞集落刺激因子/抗菌药物/血管内皮生长因子Key words
diabetic foot/infection/recombinant human granulocyte colony stimulating factor/antibacterials/vascular endothelial growth factor分类
马克思主义、列宁主义、毛泽东思想、邓小平理论引用本文复制引用
赵汉儒..重组人粒细胞集落刺激因子联合抗菌药物对糖尿病足感染患者VEGF及Flt-1的影响[J].检验医学与临床,2017,14(16):2411-2413,3.
