摘要
Abstract
Objective To investigate the effect of interleukin-17(IL-17) in lung tissue on the condition and survival of patients with chronic obstructive pulmonary disease(COPD).Methods Totally 68 cases in our hospital from February 2013 to May 2016 were due to lung cancer patients with pulmonary lobectomy were selected,according to smoking and expiratory volume ratio of FVC(FEV1/FVC) <70%,patients were divided into non-smoking non COPD group(n=21),smoking non COPD groups(n=23),smoking COPD group(n=24).The relative expression of IL-17 in the 3 groups was compared,using Pearson correlation analysis on the relative expression of IL-17 in the trachea and lung parenchyma respectively with the smoking index,FEV1% predicted value,body mass index(BMI) numerical correlation detection.Results The relative expression levels of IL-17 in the organs of the smoking COPD group and the smoking non COPD group were(7.4±2.4) and (7.5±2.2)pg/mL,(5.4±3.2) and (6.5±2.4)pg/mL,smoking COPD group was higher than that in smoking non COPD group,the difference was statistically significant(P<0.05).Smoking index was positively related to the expression of IL-17 in trachea and lung parenchyma,and the expression of IL-17 in lung parenchyma was negatively correlated with FEV1% predictive value,DLCO% predictive value and BMI,and positively correlated with assessment test score.Conclusion Smoking can increase the expression of IL-17 in the trachea and lung parenchyma,and increase the expression of IL-17,which further results in the aggravation of COPD and the survival of the patients.关键词
白细胞介素-17/慢性阻塞性肺疾病/生存状况Key words
IL-17/chronic obstructive pulmonary disease/survival condition分类
社会科学
