临床骨科杂志2017，Vol.20Issue(4)：456-458,3.DOI:10.3969/j.issn.1008-0287.2017.04.026
全膝关节置换围手术期应用氨甲环酸的有效性和安全性
Efficacy and safety of tranexamic acid on blood loss in total knee arthroplasty
高英健 1王伟力1
作者信息
- 1. 上海交通大学医学院附属仁济医院南院骨科,上海 201112
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of intravenous and topical tranexamic acid(TXA) on blood loss in total knee arthroplasty.Methods The 25 patients who did not receive TXA were controls,whereas the other 25 patients who received intravenous and topical TXA randomly constituted the treatment group.Comparison was made between both groups with regard to intra-operative blood loss,postoperative drainage volume,postoperative reduction in haemoglobin and haematocrit levels,blood transfusion rate,incidence rate of deep vein thrombosis or pulmonary embolism.Results Intra-operative blood loss: treatment group (50.21±15.37)ml and control group (70.50±11.15)ml (P<0.05);postoperative drainage volume at d1,d2 postoperation: treatment group (105.34±34.98)ml and(45.25±15.29)ml,control group(119.56±36.46)ml and(70.54±20.07)ml(P<0.05);postoperative reduction in haemoglobin and haematocrit levels: d1 treatment group(23.11±7.45) g/L and 7.69%±2.16%,control group (31.15±12.21) g/L and 9.87%±4.75% (P<0.05);d3 treatment group (29.73±10.78) g/L and 8.13%±3.22%,control group(39.64±8.77) g/L and 10.46%±4.01% (P<0.05);d6 treatment group(30.58±14.11) g/L and 9.69%±3.95%,control group(40.16±11.10) g/L and 11.01%±3.15%(P<0.05);d9 treatment group(19.85±10.84) g/L and 4.20%±2.11%,control group(30.05±9.68) g/L and 4.57%±2.01% (P<0.05);3 patients in the control group received blood transfusion(P<0.05).No patient was diagnosed deep vein thrombosis or pulmonary embolism.Conclusions 1 g intravenous TXA given 10 minutes prior to TKA and 1 g topical TXA given before closing incision is an effective and safe means of decreasing blood loss and reduction in haemoglobin concentrations,without increasing the risk of thromboembolic events.关键词
全膝关节置换/氨甲环酸/出血Key words
total knee arthroplasty/tranexamic acid/blood loss分类
医药卫生引用本文复制引用
高英健,王伟力..全膝关节置换围手术期应用氨甲环酸的有效性和安全性[J].临床骨科杂志,2017,20(4):456-458,3.
