生物骨科材料与临床研究2017，Vol.14Issue(4)：11-14,4.DOI:10.3969/j.issn.1672-5972.2017.04.003
柠檬酸钙在体外条件下对新鲜血液影响的实验研究
In vitro study of the effect of calcium citrate on the fresh blood
摘要
Abstract
Objective To study the affect of calcium citrate on the fresh blood in vitro.Method In this study,erythrocyte hemolysis rate was calculated.Various amounts of calcium citrate were added into the blood serums.The concentrations of the calcium ion in the treated blood serums were measured.After that,various amounts of calcium citrate were added into the fresh blood.The concentrations of blood calcium before and after blood clotting,the time of blood clotting and the volumes of the blood clots were measured respectively.Results Erythrocyte hemolysis rate is about 2.94％,the concentration of serum calcium increased with calcium citrate addition.The concentrations of calcium ion in the blood clots were significantly enhanced by adding the calcium citrate.The time of blood clotting was delayed,when the calcium citrate dissolved in the fresh blood,the concentration ofserum calcium was proper for fracture healing,the calcium ions could be deposited in the blood clots,which can provide the source of calcium ions for the later bone healing.Conclusion Calcium citrate exhibit excellent biocompatibility.Calcium citrate as biomedical materials has a huge market potential and the good market prospect.关键词
柠檬酸钙/骨修复材料/血清钙/钙离子/骨折愈合Key words
Calcium citrate/Bone repair materials/Serum calcium/Calcium ion/Fracture healing分类
医药卫生引用本文复制引用
彭磊,杨枚,周英勇,赵志蓉,刘建莉..柠檬酸钙在体外条件下对新鲜血液影响的实验研究[J].生物骨科材料与临床研究,2017,14(4):11-14,4.基金项目
国家自然科学基金资助项目(81460339),海南省科技厅资助项目(SF201416),海南省自然科学基金资助项目(514216),海南省科技合作专项资助项目(KJHZ2015-05),海南省卫生厅重点项目课题项目(2013-06),海南省科学技术厅(ZDXM20110051),浙江省卫生厅:(2009B107) （81460339）
