天津中医药2017，Vol.34Issue(8)：518-521,4.DOI:10.11656/j.issn.1672-1519.2017.08.04
回顾性分析类风湿性关节炎相关间质性肺病中医证型特征及疾病早发影响因素
Retrospective analysis on characteristics of traditional Chinese medicine syndrome and influence factors related to early onset of rheumatoid arthritis-associated interstitial lung disease
摘要
Abstract
[Objective] To investigate the characteristics of traditional Chinese medicine (TCM) syndrome and influence factors related to early onset of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). [Methods] Clinical data, such as gender, age, smoking history, symptoms and signs, TCM syndrome, diagnostic time for RA and RA-ILD and characteristics of chest HRCT, of inpatient with RA-ILD, were analyzed retrospectively. Onset time, pathological types and influence factors related to early onset of RA-ILD were evaluated. [Results] A total of 130 patients were filtered and 11 patients were deleted. So 119 patients were identified, of whom 54 liver-kidney yin deficiency type, 36 asthenia of qi and blood type, 19 beriberoid pyretic arthralgia type and 10 wind-cold-damp retention type. The mean and median onset time respectively were 11 years and 7 years of these patients, and both of them showed a trend as beriberoid pyretic arthralgia type<wind-cold-damp retention type<asthenia of qi and blood type<liver-kidney yin deficiency type with significant differences. UIP (65.5%) and NSIP (30.3%) were the main pathological types. Iincidence rate of beriberoid pyretic arthralgia type (52.6%) and liver-kidney yin deficiency type(96.3%) in UIP and wind-cold-damp retention type(90.0%) and asthenia of qi and blood type(55.6%) in NSIP were significant higher. The results of multivariate Cox proportional hazards regression analysis showed that TCM syndrome of RA was the influence factor related to early onset (≤7 years) of RA-ILD, and excess syndrome of RA raised the risk two times. [Conclusion] There is a certain degree of correlation between TCM syndrome of RA and pathological type of RA-ILD, and onset times of RA-ILD of beriberoid pyretic arthralgia type and wind-cold-damp retention type are earlier than the other types. This conclusion should be further confirmed by prospective studies.关键词
类风湿性关节炎/间质性肺病/中医证型/影响因素Key words
rheumatoid arthritis/interstitial lung disease/traditional Chinese medicine syndrome/influence factor分类
医药卫生引用本文复制引用
张磊,刘琦,刘旻,吴沅皞..回顾性分析类风湿性关节炎相关间质性肺病中医证型特征及疾病早发影响因素[J].天津中医药,2017,34(8):518-521,4.基金项目
国家自然科学基金项目(81473635) （81473635）
国家自然科学基金项目(81503506) （81503506）
国家自然科学基金项目(81673927). （81673927）
