天津中医药2017，Vol.34Issue(8)：565-569,5.DOI:10.11656/j.issn.1672-1519.2017.08.19
复方丹参片剂与黏附微丸体外释放对比研究
Studies on differences between Fufang Danshen tablets and Fufang Danshen adhesion pellets release in vitro
摘要
Abstract
[Objective] Establish an HPLC method to determinate salviaacidB ,tanshinoneⅡA and four panaxsapoins:Notoginsenoside R1, ginsenoside Rg1,ginsenoside Rd,ginsenoside Rb1in FufangDanshen adhesion pellets. Meanwhile, compare release difference of the two dosage form in vitro. [Methods] The pellets of compound salvia miltiorrhiza were prepared by extrusion-spheronization method. The dissolution rate of the six components in vitro and the dissolution rate and cumulative dissolution rate of compound Danshen Tablets and adhesive pellets were compared by using the phosphate buffer solution with pH6.8. [Results] Content of notoginsenoside R1 in Fufang Danshen adhesion pellets and Fufang Danshen tablets was 4.02%and 2.19%, ginsenoside Rg1 was 22.31%and 8.73%;ginsenoside Rb1 was 14.33%and 7.69%;ginsenoside Rd was 3.29%and 1.56%;salviaacid B was 17.41%and 21.70%;tanshinoneⅡA was 0.34%and 1.17%. The dissolution results showed that the total dissolution rate of the six components in the compound Danshen tablets can reach 90% within 120min, compared with the sustained release of the components of the pellets, and release in the release medium. [Conclusion] Compared with compound Danshen tablets and Compound Danshen Adhesive Pellets, the retention time in vivo is long, the release rate is slow and prolonged, and the drug action time can be prolonged, which indicated pellets can be sustained release in vivo.关键词
复方丹参黏附微丸/复方丹参片/体外溶出Key words
Fufang Danshen adhesion pellets/Fufang Danshen tablets/release in vitro分类
医药卫生引用本文复制引用
陈笑南,黎丹奇,赵梦迪,杜守颖,陆洋,李鹏跃..复方丹参片剂与黏附微丸体外释放对比研究[J].天津中医药,2017,34(8):565-569,5.基金项目
国家"重大新药创制"科技重大专项(014ZX09301306-008) （014ZX09301306-008）
北京市科技新星计划项目(xx2015A048). （xx2015A048）
