摘要
Abstract
Objective To study the clinical effect of pregabalin combined with etoricoxib in the treatment of the pain of knee osteoarthritis.Methods A total of 80 cases of patients with knee osteoarthritis pain were selected from February 2014 to February 2016 in Shangqiu First People′s Hospital,which were divided into control group and observation group according to random table number method,40 cases in each group.Observation group was given pregabalin combined with etoricoxib,control group was treated with etoricoxi,both groups were treated for 8 weeks.The two groups of VAS scores and WOMAC scores before treatment and after treatment of 1,4,8 weeks and the SAS scores,PSQI scores and liver and kidney function(ALT,AST,Cr,BUN) were compared between the two groups,and the incidence of adverse reactions were observed.Results Before treatment,no statistically significant differencs of VAS scores or WOMAC score was found between the two groups(P>0.05);after treatment of 1,4 and 8 weeks,the VAS scores and WOMAC scores of observation group were lower than control group(P<0.05),the VAS scores and WOMAC scores of two groups were lower than prior treatment(P<0.05).Before treatment,no statistically significant differencs of SAS scores or PSQI scores was found between the two groups(P>0.05);after treatment,the SAS scores and PSQI scores of observation group were lower than control group(P<0.05);the SAS scores of two groups were lower than prior treatment,PSQI scores of observation group were lower than prior treatment(P<0.05).Before and after treatment,no statistically significant differencs of ALT、AST、Cr or BUN levels was found between the two groups(P>0.05).The incidence of adverse reactions of observation group was lower than control group(P<0.05).Conclusion Pregabalin combined with etoricoxib have an obviously clinical effect in the treatment of the pain of knee osteoarthritis,it has good analgesic effect,which can significantly improve the knee joint function,degree of anxiety and sleep quality,and with high safety.关键词
骨关节炎,膝/疼痛/依托考昔/普瑞巴林/治疗结果Key words
Osteoarthritis,knee/Pain/Etoricoxib/Pregabalin/Treatment outcome分类
医药卫生
