摘要
Abstract
Objective To compare the clinical curative effect and safety of radiotherapy combined pemetrexed anddocetaxel on the treatment of NSCLC patients with failure of targeted therapy combined brain transfer.Methods From April 2012 to October 2015,77 NSCLC patients combined brain transfer with failure of targeted treatment were includedfrom the First Affiliated Hospital of Nanyang Medical College,which divided into the pemetrexed group (39 cases) and the docetaxel group(38 cases).Pemetrexed group was given radiotherapy combined with pemetrexed,and docetaxel was given radiotherapy combined with docetaxel.The clinical efficacy,side effects and prognosis of the two groups of patients were compared.Results The two groups′ RR comparison difference has no statistical significance(P=0.347),the pemetrexed group of DCR was significantly higher than the docetaxel group (P=0.041),the pemetrexed group′s anemia,thrombocytopenia,nausea,vomiting and anorexia ratio was significantly lower than the docetaxel group (P<0.05),the pemetrexed group′s median PFS was 6.6 months,the docetaxel group′s median PFS was 4.5 months,with significant difference (P<0.05);the Median OS of the two group have no statistical significance (P>0.05).Conclusion Radiotherapy combined with pemetrexed in the treatment of NSCLC target therapy failure combined with brain metastases in patients with better than docetaxel,less toxic side effects,can improve the patient′s disease control rate,prolong the progression-free survival.关键词
癌,非小细胞肺/分子靶向治疗/疗效比较研究Key words
Carcinoma,non-small-cell lung/Molecular targeted therapy/Comparative effectiveness research分类
医药卫生
