中国全科医学2017，Vol.20Issue(z1)：96-98,3.
乙肝疫苗联合乙肝免疫球蛋白阻断乙肝母婴垂直传播的疗效及影响因素研究
Clinical Effect of Hepatitis B Vaccines Combined with Hepatitis B Immunoglobulin on Interrupting Mother-to-child Perpendicular Transmission and the Influencing Factors
摘要
Abstract
Objective To explore the clinical effect of hepatitis B vaccines combined with hepatitis B immunoglobulin on interrupting mother-to-child perpendicular transmission(MTCT) and the influencing factors.Methods A total of 80 pregnant woman suffering from positive HBsAg were selected in Jiangshan City People′s Hospital of Zhejiang from June 2012 to June 2014,and 80 of their newborns.Neonatal were injected with hepatitis B immunoglobulin with 24 h after birth,and were provided with hepatitis B vaccination in line with "0-1-6" procedure.Neonatal were tested for positive rate of HBsAg and HBsAb,and were compared for different delivery modes,prenatal immune condition,and the HBsAg positive rate of "big three positive" and "small three positive"of pregnant women.Results Among all neonatal,6 were tested as positive HBsAg,and the positive rate was 7.5%;the positive rate of HBsAg was 56.3%.No significant difference was found in HBsAg positive rate between newborns with different feeding methods,delivery methods and pre pregnancy HBIG inoculation(P>0.05).The HBsAg positive rate of newborns of "big three positive " is higher than that of "small three positive"(P<0.05).Conclusion The vertical transmission rate of HBV can be reduced via combined vaccination of hepatitis B vaccine and immunoglobulin.The positive rate of HBsAg of neonatal birthed by pregnant women with "big three positive"was high.关键词
乙型肝炎/乙型肝炎疫苗/乙型肝炎免疫球蛋白/母婴垂直传播/治疗结果/影响因素分析Key words
Hepatitis B/Hepatitis B vaccines/Hepatitis B immunoglobulin/Mother-to-child perpendicular transmission/Treatment outcome/Root cause analysis分类
医药卫生引用本文复制引用
郑积才,陈和敏..乙肝疫苗联合乙肝免疫球蛋白阻断乙肝母婴垂直传播的疗效及影响因素研究[J].中国全科医学,2017,20(z1):96-98,3.
