摘要
Abstract
Objective To investigate the correlation between bilirubin peak and β2-microglobulin,cystatin C,urea nitrogen and creatinine in neonatal hyperbilirubinemia.Methods A total of 387 neonates with hyperbilirubinemia were selected from January 2015 to November 2016 in Xiantao First People′s Hospital Affiliated to Yangtze University,which were divided into mild to moderate group(n=236) and severe group(n=151) according to the relevant standards in the expert consensus of neonatal hyperbilirubinemia.The bilirubin peak,β2-microglobulin,cystatin C,urea nitrogen and creatinine were detected and compared between the two groups,and the correlation between them were analyzed.Results No statistically significant difference of creatinine was found between the two groups(P>0.05);the severe group of bilirubin peak,β2-microglobulin,cystatin C,urea nitrogen were higher than mild to moderate group(P<0.05).There were positive correlation and linear relationships between bilirubin peak and the presence of β2-microglobulin and cystatin C(r=0.323,0.298,P<0.05),there was no correlation and linear relationships between bilirubin peak and urea nitrogen,creatinine(r=0.092,0.126,P>0.05).Conclusion The bilirubin peak of neonatal hyperbilirubinemia is significantly associated with β2-microglobulin and cystatin C,and β2-microglobulin and cystatin C which are used to assess the effects of hyperbilirubinemia with renal damage has a certain clinical value.关键词
高胆红素血症,新生儿/胆红素峰值/β2-微球蛋白/胱抑素CKey words
Hyperbilirubinemia,neonatal/Bilirubin peak/β2-microglobulin/Cystatin C/Correlation分类
医药卫生
