摘要
Abstract
Objective To observe the effect of salvage chemotherapy in the treatment of patients with severe lung cancer.Methods 80 cases of severe lung cancer in Guangxi Tumor Hospital,Minzu Hospital of Guangxi Zhuang Autonomous Region,the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from June 2012 to June 2014 as the research object,divided into the observation group and the control group using a random number table method,40 cases in each group.The control group were treated with docetaxel plus cisplatin chemotherapy scheme,the observation group by docetaxel plus oxaliplatin salvage chemotherapy.The chemotherapy effect,progression free time (TTP),overall survival(OS),and toxic and side effects were observed in the two groups.Results The effective rate of chemotherapy in the observation group was〔67.5% (27/40)〕 higher than that in the control group〔50.0% (20/40)〕 (χ2=6.319,P<0.05).The TTP and OS in the observation group were longer than those in the control group (P<0.05).The incidence ofⅠ-Ⅱ degree granulocyte count reduction,platelet count reduction,hemoglobin decreased,abnormal ALT and abnormal BUN,vomiting and nausea in the observation group were lower than those in the control group,the incidence of peripheral neuritis and diarrhea in the observation group were higher than those in the control group (P<0.05).The improvement rate of Karnofsky functional status (KPS) score in the observation group was〔35.0%(14/40)〕 higher than that in the control group〔35.0%(14/40)〕 (χ2=5.623,P<0.05).Conclusion The critical stage of lung cancer is treated with docetaxel combined with oxaliplatin in the rescue of chemotherapy,with significant short-term efficacy and toxicity of chemotherapy toxicity of kidney and liver,blood toxicity lighter,can effectively improve the quality of life of patients,is ideal regimen in patients with severe lung cancer treatment.关键词
肺肿瘤/抗肿瘤联合化疗方案/多西他赛/奥沙利铂Key words
Lung neoplasms/Antineoplastic combined chemotherapy protocols/Docetaxel/Oxaliplatin分类
医药卫生
