中国全科医学2017，Vol.20Issue(z2)：116-118,3.
妊娠期肝内胆汁郁积症合并妊娠期糖尿病诊治分析
Diagnosis and Treatment of Intrahepatic Cholestasis of Pregnancy and Gestation Diabetes Mellitus
摘要
Abstract
Objective To investigate the perinatal outcome of intrahepatic cholestasis of pregnancy(ICP) and gestational diabetes mellitus(GDM).Methods 16 patients with ICP and GDM in 451th Military Hospital from January 2010 to January 2015 as study group,105 patients with ICP as control group.The complications,delivery and perinatal outcomes were observed in the two groups.Results The incidence of PHI and severe ICP in the study group was 12.5%(2/16) and 25.0%(4/16),respectively,higher than that in the control group 1.0%(1/105) and 4.8%(5/105),the difference was statistically significant(P=0.046 and 0.018).The average gestational age in the study group was 36.6 weeks,and the control group was 36.7 weeks,the difference was not statistically significant(P=0.545).The incidence of premature delivery in the study group was 25.0%(4/16),higher than that in the control group 3.8%(4/105),and the difference was statistically significant(P=0.001).The cesarean section rate of the two groups was 87.5%(14/16) and 85.7%(90/105),respectively,the difference was not statistically significant(P=0.848).There were no significant differences in the incidence of meconium stained amniotic fluid,premature rupture of membranes,fetal distress,fetal malformation,neonatal asphyxia,perinatal death,macrosomia,and low birth weight infants between the two groups(P>0.05).The incidence of hypoglycemia in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).The 1 min Apgar score of the study group was 8.25 points,which was lower than that of the control group(8.87),the difference was statistically significant(P=0.02).Conclusion The incidence of perinatal maternal and neonatal morbidity increased with the ICP and GDM,and the clinical treatment should be closely monitored.关键词
胆汁淤积,肝内/糖尿病,妊娠/妊娠结局Key words
Cholestasis,intrahepatic/Diabetes,gestational/Pregnancy outcome分类
医药卫生引用本文复制引用
梁海霞,李玉虹,郭一卜,王杜鹃,张珂珂,单思繁,黄向红,王小美..妊娠期肝内胆汁郁积症合并妊娠期糖尿病诊治分析[J].中国全科医学,2017,20(z2):116-118,3.基金项目
西安市医学攻关项目[SF1324(4)] （4）
