摘要
Abstract
Objective To investigate the effects of target-controlled infusion (TCI) propofol on the induction of anesthesia in patients with different degrees of liver cirrhosis.Methods Fifty-six patients who underwent abdominal surgery from May 2014 to July 2016 at the Chengdu Public Health Clinical Medical Center were selected as the subjects.According to the criteria of child-pugh grading,the normal liver function patients with non-cirrhosis as a control group,20 patients with liver cirrhosis and liver function as a group of patients as A group,25 patients with liver cirrhosis and liver function for the B or C patients as B group,patients were TCI propof the levels of plasma albumin,bilirubin,and urea nitrogen were compared between the three groups of patients,and the sensory scores of the three groups were compared〔the sedation alert score (improved OAA/S score ≤1)〕 and the bispectral spectrum Index (BIS) 50,the propofol target chamber,the concentration and the amount of propofol.Results The levels of plasma albumin in group A and B were significantly lower than those in control group (P<0.05).There was no significant difference in plasma albumin level between preoperative A and B groups (P>0.05).The levels of serum albumin in group A were lower than those in control group (P<0.05).The levels of bilirubin in group B were higher than those in control group (P<0.05).There was no significant difference in the levels of bilirubin in group A and control group (P>0.05).There was no significant difference in the levels of blood urea nitrogen (P>0.05).When the consciousness of the patients disappeared,the propofol concentration,propofol target concentration and dosage of group A were higher than those of the control group,the level of group B was lower than that of control group and group A,the difference was statistically (P<0.05).At the BIS value of 50,the propofol concentration,propofol target concentration and dosage of group A and B were lower than those of control group,the values of group B were lower than group A,the difference was statistically significant (P<0.05).Conclusion With the increase of liver cirrhosis,the amount of propofol required in anesthesia induction is lower.关键词
肝硬化/丙泊酚/靶控输注/麻醉Key words
Liver cirrhosis/Propofol/Target controlled infusion/Anesthesia分类
医药卫生
