中国畜牧兽医2017，Vol.44Issue(8)：2523-2528,6.DOI:10.16431/j.cnki.1671-7236.2017.08.043
硫酸头孢喹肟脂质体的毒理学试验及安全性评价
Toxicology Test and Safety Evaluation of Cefquinome Sulfate Liposomes
摘要
Abstract
The purpose of this study was to evaluate the safety of the cefquinome sulfate liposomes by using the acute toxicity test,local irritation test and chronic toxicity test.The results showed that the LD50 of cefquinome sulfate liposomes was 639.73 mg/kg after intramuscular injection of its suspension and 95％confidence interval was 573.06 to 714.17 mg/kg.There was no significant stimulation to muscle.Subchronic toxicity test showed that the weight,haematological indexes and biochemical criterion of rabbits in variety dose had no significant difference compared with normal group(P>0.05).There was no visible pathological changes on the liver,kidney histology.According to pathological observation,the structure of liver and kidney were clear in treated and middle dose groups,but there existed disorganized hepatic cell cord in the liver and hemorrhag between glomerulopathy,tubulointerstitial and hepatic sinusoids in high dose group.All results proved that the cefquinome sulfate liposomes was safe and reliable based on the animal experiments.关键词
硫酸头孢喹肟/脂质体/急性毒性/刺激性/安全性评价Key words
cefquinome sulfate/liposomes/acute toxicity/local irritation/safety evaluation分类
农业科技引用本文复制引用
吴海港,徐光科,胡静,刘锦妮,陈钦玺,张迎冰,姬万民,易本驰,马云..硫酸头孢喹肟脂质体的毒理学试验及安全性评价[J].中国畜牧兽医,2017,44(8):2523-2528,6.基金项目
河南省高等学校重点科研项目计划(15A230029) （15A230029）
信阳市科技发展计划项目(150017) （150017）
