中国药理学通报2017，Vol.33Issue(9)：1185-1190,6.DOI:10.3969/j.issn.1001-1978.2017.09.001
Ⅰ型单纯疱疹病毒潜伏感染及其应激复发
The latent infection of HSV-1 and stress-induced reactivation
摘要
Abstract
Herpes simplex virus type Ⅰ(HSV-1) is a common pathogen, and human is the only natural host of it.Following a period of lytic replication in epithelial cells, HSV-1 enters axon terminals of sensory neurons and then travels via retrograde transport to the sensory ganglia where latency can be established.Upon the stimulation of some stressors, the latent virus can reactivate, leading to recurrent diseases.Therefore, to clarify the mechanism of HSV-1 latent infection and stress-induced reactivation will offer new insights into the prevention, treatment and control of HSV-1 infection.In this review, we describes the mechanisms underlying HSV-1 latent infection and stress-induced reactivation.关键词
Ⅰ型单纯疱疹病毒/潜伏/复发/应激/Ⅰ型干扰素/免疫逃逸Key words
HSV-1/latency/reactivation/stress/type I interferon/immune evasion分类
医药卫生引用本文复制引用
罗卓,颜畅,李怡芳,栗原博,何蓉蓉..Ⅰ型单纯疱疹病毒潜伏感染及其应激复发[J].中国药理学通报,2017,33(9):1185-1190,6.基金项目
国家自然科学基金资助项目(No 81573675,81622050,81673709) （No 81573675,81622050,81673709）
