中国药理学通报2017，Vol.33Issue(9)：1190-1194,5.DOI:10.3969/j.issn.1001-1978.2017.09.002
1-磷酸鞘氨醇及受体对自身免疫性疾病血管新生的影响
Effects of sphingosine-1-phosphate andits receptors on angiogenesis in autoimmune diseases
摘要
Abstract
Sphingosine-1-phosphate(S1P) is an important bioactive lipid produced from cell membrane sphingomyelin metabolism process.S1P and cell membrane surface S1P receptors(S1PR1-5) are G protein coupled receptors(GPCRs), which influence the formation of new blood vessels in the immune system via combining the related inflammatory signaling pathway.This review describes briefly the effects of S1P and S1PRs on autoimmune disease angiogenesis through intracellular signal transduction, such as rheumatoid arthritis, multiple sclerosis, colitis, systemic lupus erythematosus.Further research will be a new therapeutic target on vascular inflammation of autoimmune diseases.关键词
1-磷酸鞘氨醇/1-磷酸鞘氨醇受体/G蛋白偶联受体/自身免疫性疾病/血管生成/炎症Key words
sphingosine-1-phosphate/sphingosine-1-phosphate receptors/G protein coupled receptors/autoimmune diseases/angiogenesis/inflammation分类
医药卫生引用本文复制引用
张峥嵘,吴虹,戴丽,王文宇,邓然,李锋,傅俊..1-磷酸鞘氨醇及受体对自身免疫性疾病血管新生的影响[J].中国药理学通报,2017,33(9):1190-1194,5.基金项目
国家自然科学基金资助项目(No 81473400) （No 81473400）
安徽中医药大学探索性研究性项目(No 2016ts072) （No 2016ts072）
